Title:
UROTHELIAL CANCER DIAGNOSIS AND THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2015/020122
Kind Code:
A1
Abstract:
The present invention provides an inspection method for determining whether a urothelial cancer is superficial or invasive, said method including measurement of the expression level of at least one miRNA selected from the group consisting of miR-130b, miR-301a, miR-301b and miR-210. Also provided are a test reagent, urothelial cancer therapeutic agent, and urothelial cancer therapeutic effect evaluation method for the inspection method.
Inventors:
TSUJIKAWA KAZUTAKE (JP)
NONOMURA NORIO (JP)
JINGUSHI KENTAROU (JP)
UEDA YUKO (JP)
UEMURA MOTOHIDE (JP)
FUJITA KAZUTOSHI (JP)
NONOMURA NORIO (JP)
JINGUSHI KENTAROU (JP)
UEDA YUKO (JP)
UEMURA MOTOHIDE (JP)
FUJITA KAZUTOSHI (JP)
Application Number:
PCT/JP2014/070811
Publication Date:
February 12, 2015
Filing Date:
August 07, 2014
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12Q1/68; A61K31/7105; A61K38/00; A61K48/00; A61P13/02; A61P35/00; A61P43/00; G01N33/50; C12N15/09; C12N15/113
Domestic Patent References:
| WO2012174282A2 | 2012-12-20 |
Foreign References:
| JP2009100687A | 2009-05-14 | |||
| JP2008519606A | 2008-06-12 | |||
| JP2009532392A | 2009-09-10 | |||
| JP2010538653A | 2010-12-16 |
Other References:
HWANG T. I-S. ET AL.: "Dysregulated microRNA expression in bladder cancer by microRNA microarray", INT. J. UROL., vol. 17, no. 1, 2010, pages A164
LIU Y. ET AL.: "Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells", PLOS ONE, vol. 7, no. 12, 2012, pages E52280
HIROSHI EGAWA ET AL.: "miR-130family Bunshi o Hyoteki to shita Boko Gan Chiryo Soyaku", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN PROGRAM YOSHISHU (WEB, vol. 36, 20 November 2013 (2013-11-20), pages 1P- 0843
HUANG X. ET AL.: "Extracellular microRNAs in urologic malignancies: chances and challenges", INT. J. MOL. SCI., vol. 14, no. 7, July 2013 (2013-07-01), pages 14785 - 99, XP055245916, DOI: doi:10.3390/ijms140714785
PIGNOT G. ET AL.: "microRNA expression profile in a large series of bladder tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle- invasive bladder cancer", INT. J. CANCER., vol. 132, no. 11, June 2013 (2013-06-01), pages 2479 - 91, XP055210898, DOI: doi:10.1002/ijc.27949
LIU Y. ET AL.: "Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells", PLOS ONE, vol. 7, no. 12, 2012, pages E52280
HIROSHI EGAWA ET AL.: "miR-130family Bunshi o Hyoteki to shita Boko Gan Chiryo Soyaku", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN PROGRAM YOSHISHU (WEB, vol. 36, 20 November 2013 (2013-11-20), pages 1P- 0843
HUANG X. ET AL.: "Extracellular microRNAs in urologic malignancies: chances and challenges", INT. J. MOL. SCI., vol. 14, no. 7, July 2013 (2013-07-01), pages 14785 - 99, XP055245916, DOI: doi:10.3390/ijms140714785
PIGNOT G. ET AL.: "microRNA expression profile in a large series of bladder tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle- invasive bladder cancer", INT. J. CANCER., vol. 132, no. 11, June 2013 (2013-06-01), pages 2479 - 91, XP055210898, DOI: doi:10.1002/ijc.27949
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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