Title:
USE OF [(1R)-1-(2-CHLOROPHENYL)-2-(TETRAZOL-2-YL)ETHYL] CARBAMATE IN COMBINATION THERAPY
Document Type and Number:
WIPO Patent Application WO/2019/182376
Kind Code:
A1
Abstract:
The present disclosure provides combination therapy using [(1R)-1-(2-chlorophenyl)-2-(tetrazol-2-yl)ethyl] carbamate (cenobamate) and one or more antiepileptic drugs for the prevention or treatment of a neurological disorder such as epilepsy.
Inventors:
KAMIN MARC (US)
VERNILLET LAURENT (US)
VERNILLET LAURENT (US)
Application Number:
PCT/KR2019/003294
Publication Date:
September 26, 2019
Filing Date:
March 21, 2019
Export Citation:
Assignee:
SK BIOPHARMACEUTICALS CO LTD (KR)
International Classes:
A61K31/4166; A61K31/41; A61K31/4196; A61K31/515; A61K31/55; A61P25/00
Domestic Patent References:
| WO2017075222A1 | 2017-05-04 |
Other References:
KIM SUN-YOUNG: "Viva100] SK Biopharm' s new antiepileptic drug, 'Cenobamate' is about to be commercialized... It aims at 1 trillion won in annual sales, the world' s No. 1 'Vimpat", VIVA 100 > HEALTH, 7 December 2017 (2017-12-07), pages 1 - 3, XP009523682, Retrieved from the Internet
GREGORY KRAUSS, JACQUELINE FRENCH, MARC KAMIN, PALANICHAMY ILANKUMARAN: "Seizure freedom with YKP3089as adjunctive therapy for refractory partial-onset seizures in double-blind placebo- controlled trials (P2.019", NEUROLOGY, vol. 86, no. 16, 4 April 2016 (2016-04-04), XP009523686, ISSN: 0028-3878
GAETANO ZACCARA; EMILIO PERUCCA: "Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs", EPILEPTIC DISORDERS, vol. 16, no. 4, 31 December 2014 (2014-12-31), pages 409 - 431, XP055636311, ISSN: 1294-9361, DOI: 10.1684/epd.2014.0714
VERNILLET, L.; KAMIN, M.: "Drug-drug interactions between cenobamate and other antiepileptic drugs: Results from phase 1 studies with carbamazepine, phenobarbital, phenytoin, and divalproex sodium", AMERICAN SOCIETY FOR CLINICAL PHARMACOLOGY & THERAPEUTICS, vol. 103, no. S1, 7 February 2018 (2018-02-07), Orlando, FL. , USA, pages S91 - S97, XP009523795, ISSN: 1532-6535
GREGORY KRAUSS, JACQUELINE FRENCH, MARC KAMIN, PALANICHAMY ILANKUMARAN: "Seizure freedom with YKP3089as adjunctive therapy for refractory partial-onset seizures in double-blind placebo- controlled trials (P2.019", NEUROLOGY, vol. 86, no. 16, 4 April 2016 (2016-04-04), XP009523686, ISSN: 0028-3878
GAETANO ZACCARA; EMILIO PERUCCA: "Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs", EPILEPTIC DISORDERS, vol. 16, no. 4, 31 December 2014 (2014-12-31), pages 409 - 431, XP055636311, ISSN: 1294-9361, DOI: 10.1684/epd.2014.0714
VERNILLET, L.; KAMIN, M.: "Drug-drug interactions between cenobamate and other antiepileptic drugs: Results from phase 1 studies with carbamazepine, phenobarbital, phenytoin, and divalproex sodium", AMERICAN SOCIETY FOR CLINICAL PHARMACOLOGY & THERAPEUTICS, vol. 103, no. S1, 7 February 2018 (2018-02-07), Orlando, FL. , USA, pages S91 - S97, XP009523795, ISSN: 1532-6535
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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