Title:
USE OF 4-ARYLAMINOQUINAZOLINE HYDROXAMIC ACID COMPOUNDS IN PREPARATION OF PAIN DRUG
Document Type and Number:
WIPO Patent Application WO/2022/237456
Kind Code:
A1
Abstract:
Disclosed is the use of a series of 4-arylaminoquinazoline hydroxamic acid compounds in the preparation of a drug for treating neuropathic pain diseases, and specifically, the use of a compound as represented by formula III-2, a tautomer thereof or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating neuropathic pain diseases.
Inventors:
CHEN XIAOXIN (CN)
ZHANG LAN (CN)
LIU MIAO (CN)
ZHANG QIANRU (CN)
CHEN MOU (CN)
LONG CHAOFENG (CN)
YAO YUQIN (CN)
ZHANG LAN (CN)
LIU MIAO (CN)
ZHANG QIANRU (CN)
CHEN MOU (CN)
LONG CHAOFENG (CN)
YAO YUQIN (CN)
Application Number:
PCT/CN2022/087341
Publication Date:
November 17, 2022
Filing Date:
April 18, 2022
Export Citation:
Assignee:
GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/517; A61P25/04; A61P29/00; C07D239/94
Domestic Patent References:
| WO2016146074A1 | 2016-09-22 |
Foreign References:
| CN1784391A | 2006-06-07 | |||
| CN101142195A | 2008-03-12 | |||
| CN105669567A | 2016-06-15 | |||
| US20090111772A1 | 2009-04-30 |
Other References:
KRUKOWSKI, K. ET AL.: "HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy.", PAIN., vol. 158, no. 6, 1 June 2018 (2018-06-01)
LAWRENCE VAN HELLEPUTTE, MANDY KATER, DANA P. COOK, CAROLINE EYKENS, ELISABETH ROSSAERT, WANDA HAECK, TOM JASPERS, NATASJA GEENS, : "Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth", NEUROBIOLOGY OF DISEASE, ELSEVIER, AMSTERDAM, NL, vol. 111, 1 March 2018 (2018-03-01), AMSTERDAM, NL , pages 59 - 69, XP055465564, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2017.11.011
LAWRENCE VAN HELLEPUTTE, MANDY KATER, DANA P. COOK, CAROLINE EYKENS, ELISABETH ROSSAERT, WANDA HAECK, TOM JASPERS, NATASJA GEENS, : "Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth", NEUROBIOLOGY OF DISEASE, ELSEVIER, AMSTERDAM, NL, vol. 111, 1 March 2018 (2018-03-01), AMSTERDAM, NL , pages 59 - 69, XP055465564, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2017.11.011
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
Download PDF: