Title:
USE OF 7ALPHA-HYDROXY-ESTRADIOL, 7ALPHA-HYDROXY-DEHYDROEPIANDROSTERONE AND 7ALPHA-HYDROXY-PREGNENOLONE DERIVATIVES FOR TREATING ACUTE CELLULAR DEGENERATION
Document Type and Number:
WIPO Patent Application WO2001060375
Kind Code:
A3
Abstract:
A method is provided for treating a patient in need of therapy for acute neuronal degeneration due to metabolic compromise of central or peripheral nervous system cells comprising administering to that patient a therapeutically effective amount of a 7 alpha -hydroxy substituted steroid selected from 7 alpha -hydroxy-derivatives of estradiols, dehydroepiandrosterones and pregnenolones, and metabolic precursors thereof. Use of such compounds for manufacture of medicaments and neuroprotective compositions are also provided.
Inventors:
LATHE RICHARD FRANK (GB)
SECKL JONATHAN ROBERT (GB)
MARTIN KEITH FRANK (GB)
WULFERT ERNST ARNE (BE)
SECKL JONATHAN ROBERT (GB)
MARTIN KEITH FRANK (GB)
WULFERT ERNST ARNE (BE)
Application Number:
PCT/GB2001/000627
Publication Date:
April 04, 2002
Filing Date:
February 15, 2001
Export Citation:
Assignee:
HUNTER FLEMING LTD (GB)
UNIV EDINBURGH (GB)
BTG INT LTD (GB)
LATHE RICHARD FRANK (GB)
SECKL JONATHAN ROBERT (GB)
MARTIN KEITH FRANK (GB)
WULFERT ERNST ARNE (BE)
UNIV EDINBURGH (GB)
BTG INT LTD (GB)
LATHE RICHARD FRANK (GB)
SECKL JONATHAN ROBERT (GB)
MARTIN KEITH FRANK (GB)
WULFERT ERNST ARNE (BE)
International Classes:
A61K31/565; A61K31/567; A61K31/5685; A61K31/57; A61P9/10; A61P25/00; A61P25/02; A61P25/28; A61P43/00; C07J1/00; (IPC1-7): A61K31/565; A61K31/567; A61K31/5685; A61K31/57; A61P9/10; A61P25/28
Domestic Patent References:
| WO1997037664A2 | 1997-10-16 | |||
| WO1994003176A1 | 1994-02-17 | |||
| WO1994008588A1 | 1994-04-28 | |||
| WO1998040074A1 | 1998-09-17 | |||
| WO1997003677A1 | 1997-02-06 | |||
| WO1996040152A1 | 1996-12-19 | |||
| WO1995012402A1 | 1995-05-11 |
Foreign References:
| GB1528796A | 1978-10-18 |
Other References:
PARK-CHUNG, MIJEONG ET AL: "Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids", MOL. PHARMACOL. (1997), 52(6), 1113-1123, XP000911767
IRWIN, ROBERT P. ET AL: "Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies", J. PHARMACOL. EXP. THER. (1994), 271(2), 677-82, XP000911758
Y. AKWA ET AL.: "Astrocytes and Neurosteroids: Metabolism of Pregnenolone and Dehydroepiandrosterone. Regulation by Cell Density", THE JOURNAL OF CELL BIOLOGY, vol. 121, no. 1, 1993, pages 135 - 143, XP000911759
IRWIN, ROBERT P. ET AL: "Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies", J. PHARMACOL. EXP. THER. (1994), 271(2), 677-82, XP000911758
Y. AKWA ET AL.: "Astrocytes and Neurosteroids: Metabolism of Pregnenolone and Dehydroepiandrosterone. Regulation by Cell Density", THE JOURNAL OF CELL BIOLOGY, vol. 121, no. 1, 1993, pages 135 - 143, XP000911759
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