Title:
USE OF 9,10-ANTHRAQUINONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2010/057443
Kind Code:
A1
Abstract:
Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.
Inventors:
WANG SHUGUANG (CN)
ZHONG JIN (CN)
KONG DEYUN (CN)
HU JUE (CN)
LI BO (CN)
GAO WEN (CN)
GAI CHUNYAN (CN)
ZHUANG CHANGLONG (CN)
MAO HAITAO (CN)
ZHONG JIN (CN)
KONG DEYUN (CN)
HU JUE (CN)
LI BO (CN)
GAO WEN (CN)
GAI CHUNYAN (CN)
ZHUANG CHANGLONG (CN)
MAO HAITAO (CN)
Application Number:
PCT/CN2009/075075
Publication Date:
May 27, 2010
Filing Date:
November 23, 2009
Export Citation:
Assignee:
SHANGHAI INST PHARM INDUSTRY (CN)
WANG SHUGUANG (CN)
ZHONG JIN (CN)
KONG DEYUN (CN)
HU JUE (CN)
LI BO (CN)
GAO WEN (CN)
GAI CHUNYAN (CN)
ZHUANG CHANGLONG (CN)
MAO HAITAO (CN)
WANG SHUGUANG (CN)
ZHONG JIN (CN)
KONG DEYUN (CN)
HU JUE (CN)
LI BO (CN)
GAO WEN (CN)
GAI CHUNYAN (CN)
ZHUANG CHANGLONG (CN)
MAO HAITAO (CN)
International Classes:
A61K31/122; A61K31/185; A61K31/192; A61K31/7004; A61K31/704; A61K36/482; A61K36/708; A61K36/74; A61K36/896; A61P1/16; A61P31/14
Domestic Patent References:
| WO2008060695A2 | 2008-05-22 | |||
| WO2008097112A1 | 2008-08-14 |
Other References:
ZHANG YUNDAO.: "100 Cases of Hepatitis C Treating by Combination Therapy of Chinese Traditional Medicine and Modern Medicine.", HEBEI JOURNAL OF TRADITIONAL CHINESE MEDICINE (CHINESE)., vol. 23, no. 9., September 2001 (2001-09-01), pages 704
LI XIAOXIA ET AL.: "Progress on Chronic Hepatitis C Treating by Chinese Traditional Therapy.", ZHEJIANG JOURNAL OF TRADITIONAL CHINESE MEDICINE (CHINESE)., vol. 41, no. 4., April 2006 (2006-04-01), pages 239 - 241
ZHENG JUNHUA ET AL.: "HPLC Determination of 34 Chemical Constituents in Three Official Rhubarbs.", JOURNAL OF BEIJING MEDICAL UNIVERSITY (CHINESE)., vol. 21, no. 1., 1989, pages 54 - 56
YANG LIANRONG ET AL.: "Progress on Chemical Constituents and Pharmacology Effect of Rubia Cordifolia L.", INFORMATION ON TRADITIONAL CHINESE MEDICINE (CHINESE)., vol. 24, no. 1., 2007, pages 21 - 23
LI XIAOXIA ET AL.: "Progress on Chronic Hepatitis C Treating by Chinese Traditional Therapy.", ZHEJIANG JOURNAL OF TRADITIONAL CHINESE MEDICINE (CHINESE)., vol. 41, no. 4., April 2006 (2006-04-01), pages 239 - 241
ZHENG JUNHUA ET AL.: "HPLC Determination of 34 Chemical Constituents in Three Official Rhubarbs.", JOURNAL OF BEIJING MEDICAL UNIVERSITY (CHINESE)., vol. 21, no. 1., 1989, pages 54 - 56
YANG LIANRONG ET AL.: "Progress on Chemical Constituents and Pharmacology Effect of Rubia Cordifolia L.", INFORMATION ON TRADITIONAL CHINESE MEDICINE (CHINESE)., vol. 24, no. 1., 2007, pages 21 - 23
Attorney, Agent or Firm:
SHANGHAI ZHI XIN PATENT AGENT LTD. (Zhijun Building,No.1223 Xie Tu Rd, Shanghai 2, CN)
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