Title:
USE OF (ALPHA)-D-GLUCANS FOR PROMOTING CUTANEOUS WOUND AND ULCER HEALING
Document Type and Number:
WIPO Patent Application WO/2000/045802
Kind Code:
A2
Abstract:
The present invention provides methods of promoting the healing of cutaneous wounds and ulcers in vertebrates by administering a composition of a branched chain polymeric $g(a)-D-glucan to the wound or ulcer. In a preferred embodiment, the branched chain polymeric $g(a)-D-glucan may be hetastarch. The cutaneous wound or ulcer may be an open wound or ulcer, and may be chronic. The composiitions are useful for treating these wounds in vertebrates. The vertebrate may be a mammal such as a human, a canine, or any mammal. The composition utilized in the methods of the present invention may contain hetastarch.
Inventors:
HENLEY KARLA J (US)
Application Number:
PCT/US2000/002651
Publication Date:
August 10, 2000
Filing Date:
February 03, 2000
Assignee:
IDEXX LAB INC (US)
HENLEY KARLA J (US)
International Classes:
A61K31/19; A61K31/716; A61K31/718; A61P17/02; C08B31/12; C08B35/04; C08B37/00; (IPC1-7): A61K31/00
Domestic Patent References:
| WO1997015286A1 | 1997-05-01 | | | |
| WO1998041213A1 | 1998-09-24 | | | |
Foreign References:
| EP0343807A2 | 1989-11-29 | | | |
| EP0819703A2 | 1998-01-21 | | | |
| US4833131A | 1989-05-23 | | | |
Other References:
PASCH, J. ET AL: "Cryopreservation of keratinocytes in a monolayer" CRYOBIOLOGY, vol. 39, no. 2, September 1999 (1999-09), pages 158-168, XP000972588
DATABASE WPI Week 199504 Derwent Publications Ltd., London, GB; AN 1995-028936 XP002154457 & RU 2 011 379 A (N CAUCASUS VETERINARY RESEARCH INST.), 30 April 1994 (1994-04-30)
DATABASE WPI Week 199309 Derwent Publications Ltd., London, GB; AN 1993-071012 XP002154458 & JP 05 017332 A (SHISEIDO CO LTD.), 26 January 1993 (1993-01-26)
LALONDE, C. ET AL: "Aerosolised deferoxamine prevents lung and systemic injury caused by smoke inhalation" THE JOURNAL OF APPLIED PHYSIOLOGY, vol. 77, no. 5, 1994, pages 2057-2064, XP000972532
BRAZEAL, B.A. ET AL: "Pentafraction for superior resuscitation of the ovine thermal burn" CRITICAL CARE MEDICINE, vol. 23, no. 2, 1995, pages 332-339, XP000972460
Attorney, Agent or Firm:
Consalvi, Mary S. (L.L.P. 1299 Pennsylvania Avenue N.W. Box 34 Washington, DC, US)
Claims:
What is claimed is:
| 1. |
A method of promoting the healing of cutaneous wounds and ulcers in vertebrates comprising: administering an aDglucan composition to the cutaneous wound or ulcer. |
| 2. |
The method of claim 1 wherein the aDglucan is a branched chain polymeric aDglucan. |
| 3. |
The method of claim 2 wherein the cutaneous wound or ulcer is a cutaneous open wound or ulcer. |
| 4. |
The method of claim 2 wherein the branched chain polymeric aDglucan is hetastarch. |
| 5. |
The method of claim 3, wherein the cutaneous open wound or ulcer is selected from the group consisting of: a decubital ulcer, a dehiscence wound, an acral lick dermatitis, a laceration, and a traumatic wound. |
| 6. |
The method of claim 3 wherein the cutaneous open wound or ulcer is a venous stasis ulcer. |
| 7. |
The method of claim 3, wherein the cutaneous open wound or ulcer is a chronic cutaneous open wound or ulcer. |
| 8. |
The method of claim 3 wherein the composition comprises at least about 25 percent hetastarch. |
| 9. |
The method of claim 3 wherein the composition comprises at least about 5 percent hetastarch. |
| 10. |
The method of claim 3 wherein the composition comprises from about 40 percent to about 70 percent hetastarch. |
| 11. |
The method of claim 10 wherein the composition comprises about 50 percent hetastarch. |
| 12. |
The method of claim 10 wherein the composition further comprises about 20 mM sodium acetate. |
| 13. |
The method of claim 5 wherein the branched chain polymeric aDglucan is hetastarch. |
| 14. |
The method of claim 5 wherein the vertebrate is a mammal. |
| 15. |
The method of claim 14 wherein the mammal is a canine. |
| 16. |
The method of claim 14 wherein the mammal is a human. |
| 17. |
The method of claim 14 wherein the mammal is selected from the group consisting of a bovine, a feline, an ovine, an equine, and a porcine. |
| 18. |
A method of promoting the healing of cutaneous wounds and ulcers in vertebrates comprising: administering a composition containing a polymer of pentose to the cutaneous wound or ulcer. |
| 19. |
The method of claim 18 wherein the polymer of pentose is a branched chain polymer of pentose. |
Description:
INTERNATIONAL SEARCH j------------------) Interi nal Application No PCT/US 00/02651 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication. where appropriate, of the relevant passages Relevant to claim No. X WO 98 41213 A (LXR BIOTECHNOLOGY INC.) 1-5,7, 24 September 1998 (1998-09-24) 13-17 page 12, line 30 page 19, line 14-17 page 34, line 23-page 35, line 2 page 48, line 28-30 page 52, line 27-page 53, line 7 page 56, line 19 claims28,94,95 X DATABASE WPI 1-3,5,7, Week 199504 14-17 Derwent Publications Ltd., London, GB; AN 1995-028936 XP002154457 &RU 2 Oil 379 A (N CAUCASUS VETERINARY RESEARCH INST.), 30 April 1994 (1994-04-30) abstract X DATABASE WPI 1-3,5,7, Week 199309 14-17 Derwent Publications Ltd., London, GB; AN 1993-071012 XP002154458 &JP 05 017332 A (SHISEIDO CO LTD.), 26 January 1993 (1993-01-26) abstract X EP 0 343 807 A (SMITH AND NEPHEW UNITED 1-3,5,7, INC.) 29 November 1989 (1989-11-29) 14-17 the whole document especially page 4, line 55-page 5, line 4 A EP 0 819 703 A (MIBELLE AG COSMETICS) 1-17 21 January 1998 (1998-01-21) the whole document A US 4 833 131 A (BIOGLUCANS LP) 1-17 23 May 1989 (1989-05-23) the whole document especially claim 29 A LALONDE, C. ET AL:"Aerosolised 1-17 deferoxamine prevents lung and systemic injury caused by smoke inhalation" THE JOURNAL OF APPLIED PHYSIOLOGY, vol. 77, no. 5,1994, pages 2057-2064, XP000972532 the whole document ___ 1 INTERNATIONAL SEARCH !-------------------) lnterr nal Application No PCT/US 00/02651 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category ° Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. A BRAZEAL, B. A. ET AL:"Pentafraction for 1-17 superior resuscitation of the ovine thermal burn" CRITICAL CARE MEDICINE, vol. 23, no. 2,1995, pages 332-339, XP000972460 the whole document 1 International Application No. PCTAJS 00, 02651 FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 Continuation of Box 1. 2 Claims Nos.: 18,19 Present claims 1-3,5-7 and 14-19 relate to a rather elevated number of possible compounds. Support within the meaning of Article 6 PCT and disclosure within the meaning of Article 5 PCT is to be found, however, for only a very small proportion of the compounds claimed. In the present case, the claims so lack support, and the application so lacks disclosure, that a meaningful search over the whole of the claimed scope is impossible. Consequently, the search has been carried out for those parts of the claims which appear to be supported and disclosed, namely those parts relating to the compound hetastarch (including pentastarch and pentafraction). The applicant's attention is drawn to the fact that claims, or parts of claims, relating to inventions in respect of which no international search report has been established need not be the subject of an international preliminary examination (Rule 66.1 (e) PCT). The applicant is advised that the EPO policy when acting as an International Preliminary Examining Authority is normally not to carry out a preliminary examination on matter which has not been searched. This is the case irrespective of whether or not the claims are amended following receipt of the search report or during any Chapter II procedure. INTERNATIONAL SEARCH i------------------- Inten nal Applicatlon No iformation on patent family members PCT/US 00/02651 Patent document Publication Patent family Publication cited in search report date member (s) date WO 9715286 A 01-05-1997 AU 7519396 A 15-05-1997 WO 9841213 A 24-09-1998 AU 6565098 A 12-10-1998 EP 1024812 A 09-08-2000 RU 2011379 A 30-04-1994 NONE JP 5017332 A 26-01-1993 NONE EP 343807 A 29-11-1989 JP 2023966 A 26-01-1990 EP 819703 A 21-01-1998 DE 19730542 A 12-02-1998 US 4833131 A 23-05-1989 US 4739046 A 19-04-1988 US 4975421 A 04-12-1990 AT 71528 T 15-02-1992 AU 599045 B 12-07-1990 AU 6229686 A 10-03-1987 CA 1337408 A 24-10-1995 DE 3683479 A 27-02-1992 DE 3683479 D 27-02-1992 DK 198587 A 18-06-1987 EP 0232405 A 19-08-1987 FI 871718 A, B, 16-04-1987 JP 2550332 B 06-11-1996 JP 63500805 T 24-03-1988 KR 9008442 B 22-11-1990 NO 871603 A, B, 15-06-1987 US 4761402 A 02-08-1988 US 4818752 A 04-04-1989 NO 8701037 A 26-02-1987 US 4877777 A 31-10-1989 US4900722 A 13-02-1990
