Title:
USE AS IMMUNE ENHANCER OR PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DEMENTIA, COMPRISING PHYTOSPHINGOSINE-1-PHOSPHATE OR DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/213341
Kind Code:
A1
Abstract:
Disclosed in the present invention are a use as an immune enhancer of phytosphingosine-1-phosphate (P1P), O-cyclic P1P (cP1P), N-acetylphytosphingosine -1-phosphate (NAPS-1-P), and pharmaceutically acceptable salts thereof, and a pharmaceutical composition or vaccine for treating dementia, comprising such substance on the basis of a neuronal cell death inhibitory effect. The substance according to the present invention exhibits an effect of increasing the Th2 immune response and inhibiting the Th1 immune response and has an effect of protecting neurons as well, and thus can be useful as an immune enhancer to help the production of antibodies for the development of a dementia vaccine, as well as an agent for preventing or treating dementia.
Inventors:
CHOI MYEONG JUN (KR)
Application Number:
PCT/KR2017/003804
Publication Date:
December 14, 2017
Filing Date:
April 07, 2017
Export Citation:
Assignee:
PHYTOS CO LTD (KR)
International Classes:
A61K31/661; A61K9/127; A61K39/00; A61K39/39
Domestic Patent References:
| WO2012134134A2 | 2012-10-04 |
Foreign References:
| KR20150025286A | 2015-03-10 | |||
| KR20130094547A | 2013-08-26 | |||
| KR101003532B1 | 2010-12-28 | |||
| KR101340556B1 | 2013-12-11 | |||
| KR101514970A |
Other References:
CARRERA, L ET AL.,: "Vaccine Development to Treat Alzheimer's Disease Neuropathology in APP/PSl Transgenic Mice", INLERNATIONAL JOURNAL OF ALZHEIMER'S DISEASE, vol. 2012, 376138, 2012, XP055585805
HUGH ES, .I. E. ET AL.: "Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.", CIRCULATION RESEARCH, vol. 102, 2008, pages 950 - 958, XP055585822
MARCIANI, REV NEUROPSIQUIATR, vol. 78, 2015, pages 140 - 152
HE ET AL., NEUROBIOLOGY OF AGING, vol. 31, 2010, pages 398 - 408
LEE ET AL., J EXP MED, vol. 211, 2014, pages 1551 - 1570
CECCOM ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 2, 2014, pages 12
COUTTAS ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 2, 2014, pages 9
CZUBOWICZ AND STROSZNAJDER, vol. 50, 2014, pages 26 - 37
KOLAHDOOZ ET AL., CAN J NEURO SCI, vol. 42, 2015, pages 195 - 202
GOMEZ-BROUCHET ET AL., MOLECULAR PHARMACOLOGY, vol. 72, 2007, pages 341 - 349
GASSOWSKA ET AL., NEUROCHEM RES, vol. 39, 2014, pages 645 - 652
ROBERTO ET AL., FASEB J, vol. 18, 2004, pages 511 - 518
KIM ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 8997
CARRERA; CACABELOS, DRUG DES, vol. 2, 2013, pages 2
MARCIANI, AUSTIN ALZHEIMERS J PARKINSONS DIS, vol. 1, 2014, pages 4
HUGHERS ET AL., CIRC RES, vol. 102, 2008, pages 950 - 958
CARRERA ET AL., INTERNATIONAL JOURANL OF ALZHEIMER'S DISEASE, vol. 2012, 2012, pages 17
CARRERA ET AL., BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 12
CARRERA ET AL., BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, pages 16
S. LI; W.K. WILSON; G.J. SCHROEPFER: "Chemical synthesis of D-ribo-phytosphingosine-1-phosphate, potential modulator of cellular processes", J. LIPID RES., vol. 40, 1999, pages 117 - 125, XP002542761
"Remington's Pharmaceutical Sciences"
ROMAGNANI S1, ANN ALLERGY ASTHMA IMMUNOL., vol. 85, no. 1, July 2000 (2000-07-01), pages 9 - 18
See also references of EP 3501524A4
HUGH ES, .I. E. ET AL.: "Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.", CIRCULATION RESEARCH, vol. 102, 2008, pages 950 - 958, XP055585822
MARCIANI, REV NEUROPSIQUIATR, vol. 78, 2015, pages 140 - 152
HE ET AL., NEUROBIOLOGY OF AGING, vol. 31, 2010, pages 398 - 408
LEE ET AL., J EXP MED, vol. 211, 2014, pages 1551 - 1570
CECCOM ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 2, 2014, pages 12
COUTTAS ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 2, 2014, pages 9
CZUBOWICZ AND STROSZNAJDER, vol. 50, 2014, pages 26 - 37
KOLAHDOOZ ET AL., CAN J NEURO SCI, vol. 42, 2015, pages 195 - 202
GOMEZ-BROUCHET ET AL., MOLECULAR PHARMACOLOGY, vol. 72, 2007, pages 341 - 349
GASSOWSKA ET AL., NEUROCHEM RES, vol. 39, 2014, pages 645 - 652
ROBERTO ET AL., FASEB J, vol. 18, 2004, pages 511 - 518
KIM ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 8997
CARRERA; CACABELOS, DRUG DES, vol. 2, 2013, pages 2
MARCIANI, AUSTIN ALZHEIMERS J PARKINSONS DIS, vol. 1, 2014, pages 4
HUGHERS ET AL., CIRC RES, vol. 102, 2008, pages 950 - 958
CARRERA ET AL., INTERNATIONAL JOURANL OF ALZHEIMER'S DISEASE, vol. 2012, 2012, pages 17
CARRERA ET AL., BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 12
CARRERA ET AL., BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, pages 16
S. LI; W.K. WILSON; G.J. SCHROEPFER: "Chemical synthesis of D-ribo-phytosphingosine-1-phosphate, potential modulator of cellular processes", J. LIPID RES., vol. 40, 1999, pages 117 - 125, XP002542761
"Remington's Pharmaceutical Sciences"
ROMAGNANI S1, ANN ALLERGY ASTHMA IMMUNOL., vol. 85, no. 1, July 2000 (2000-07-01), pages 9 - 18
See also references of EP 3501524A4
Attorney, Agent or Firm:
PARK, Weonmee (KR)
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