Title:
USE OF ATAZANAVIR FOR IMPROVING THE PHARMACOKINETICS OF DRUGS METABOLIZED BY UGT1A1
Document Type and Number:
WIPO Patent Application WO2006060731
Kind Code:
A3
Abstract:
A method for improving the pharmacokinetics of an orally administered drug that is directly metabolized by UGT1A1 comprises orally administering to a mammal in need of treatment with the drug a combination of the drug or a pharmaceutically acceptable salt thereof and atazanavir or a pharmaceutically acceptable salt thereof.
Inventors:
KASSAHUN KELEM (US)
Application Number:
PCT/US2005/043782
Publication Date:
September 28, 2006
Filing Date:
December 02, 2005
Export Citation:
Assignee:
MERCK & CO INC (US)
KASSAHUN KELEM (US)
KASSAHUN KELEM (US)
International Classes:
A61K45/00; C11D7/60; C07D211/72; C07D211/84; C07D213/62; C07D213/73; C07D213/78; C23G1/08
Domestic Patent References:
| WO2003035077A1 | 2003-05-01 |
Foreign References:
| US20040192624A1 | 2004-09-30 |
Other References:
TABURET A. ET AL.: "Interaction between Atazanavir-Ritonavir and Tenofovir in Heavily Pretreated Human Immunodeficiency Virus-Infected Patients", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, no. 6, June 2004 (2004-06-01), pages 2091 - 2096, XP008119429
FLETCHER C.V. ET AL.: "Competing drug-drug interaction among multidrug antiretroviral regimens used in the treatment of HIV-infected subjects: ACTG 884", AIDS, vol. 14, no. 16, 10 November 2000 (2000-11-10), pages 2495 - 2501, XP008119427
FLETCHER C.V. ET AL.: "Competing drug-drug interaction among multidrug antiretroviral regimens used in the treatment of HIV-infected subjects: ACTG 884", AIDS, vol. 14, no. 16, 10 November 2000 (2000-11-10), pages 2495 - 2501, XP008119427
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