USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF TUMORS

Title:

USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF TUMORS

Document Type and Number:

WIPO Patent Application WO2003057148

Kind Code:

A3

Abstract:

The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor treatment therapies. The protein is also expressed in tissues from adenocarcinoma, non-melanoma, and renal carcinoma cells. Immunotherapeutic and immunoimaging agents that specifically bind to an identified brain tumor target protein are provided. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

Inventors:

MUELLER SABINE (US)
GONZALEZ-ZULUETA MIRELLA (US)
FOEHR ERIK (US)
CHIN DANIEL (US)

Application Number:

PCT/US2002/041419

Publication Date:

January 15, 2004

Filing Date:

December 23, 2002

Export Citation:

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Assignee:

AGY THERAPEUTICS INC (US)
MUELLER SABINE (US)
GONZALEZ-ZULUETA MIRELLA (US)
FOEHR ERIK (US)
CHIN DANIEL (US)

International Classes:

G01N33/50; A61B10/00; A61K39/39; A61K39/395; A61K47/48; A61K48/00; A61K49/00; A61K49/04; A61K51/00; A61P1/14; A61P3/00; A61P9/10; A61P9/14; A61P15/00; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P27/00; A61P31/00; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P41/00; A61P43/00; C12N1/21; C12N15/09; C12N15/12; C12Q1/02; C12Q1/68; G01N33/15; G01N33/574; (IPC1-7): C12N15/12; A61K38/17; C07K14/705; C07K14/72; C07K16/28; C12N1/21; C12N5/10; C12Q1/68

Domestic Patent References:

WO2000020590A2

2000-04-13

Other References: