Title:
USE OF BUTYRIC ACID COMPOUND IN PREPARATION OF DRUG FOR PREVENTING AND TREATING NEC OR NUTRITION PREPARATION
Document Type and Number:
WIPO Patent Application WO/2019/041848
Kind Code:
A1
Abstract:
Provided in the present invention is the use of a butyric acid compound in the preparation of a drug for preventing and treating necrotizing enterocolitis or a nutrition preparation, also provided is a nutrition preparation containing butyric acid which comprises a nutritional composition and a butyric acid compound, wherein the concentration of the butyric acid compound in the nutrition preparation is 0.5 to 200 mM (mmol/L). The butyric acid compound is selected from at least one of butyric acid, butyrate salts, and butyric acid derivatives. The present invention first finds that the butyric acid compound is very effective in preventing and treating necrotizing enterocolitis by adding it to a pharmaceutical or nutritional composition, including significantly reducing the incidence and mortality of necrotizing enterocolitis, shortening the duration of necrotizing enterocolitis, reducing its complications and/or reducing its severity. At the same time it also has the effects of promoting growth, immune system development and intestinal maturation.
Inventors:
WEN JIE (CN)
CAI WEI (CN)
CAI WEI (CN)
Application Number:
PCT/CN2018/084675
Publication Date:
March 07, 2019
Filing Date:
April 26, 2018
Export Citation:
Assignee:
SHANGHAI INSTITUTE OF PEDIATRIC RES (CN)
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE (CN)
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
A61K31/19; A61K31/22; A61P1/00; A61P29/00
Other References:
HAN, BINGCHAO ET AL.: "Clostridium Butyricum CGMCC0313.1 Pulvis in Preventing Necrotizing Enterocolitis in Premature Infants", CHINESE JOURNAL OF MICROECOLOGY, vol. 20, no. 6, 31 December 2008 (2008-12-31), pages 584 - 585, XP055581108
LI, XIONGBIAO ET AL.: "Molecular Basis of Butyric Acid and Folic acid in Prevention and Treatment of Gastrointestinal Diseases", WORLD CHINESE JOURNAL OF DIGESTOLOGY, vol. 14, no. 32, 31 December 2006 (2006-12-31), pages 3071 - 3080
LI, XIONGBIAO ET AL.: "Molecular Basis of Butyric Acid and Folic acid in Prevention and Treatment of Gastrointestinal Diseases", WORLD CHINESE JOURNAL OF DIGESTOLOGY, vol. 14, no. 32, 31 December 2006 (2006-12-31), pages 3071 - 3080
Attorney, Agent or Firm:
SHANGHAI HANGSOME INTELLECTUAL PROPERTY LTD. (CN)
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