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Title:
USE OF C-TYPE NATRIURETIC PEPTIDE VARIANTS TO TREAT OSTEOARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2017/100400
Kind Code:
A3
Abstract:
The disclosure relates to the use of variants of C-type natriuretic peptide (CNP) to treat osteoarthritis, to ameliorate one or more symptoms of osteoarthritis, and to treat disorders having an osteoarthritis component.

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Inventors:
O'NEILL CHARLES A (US)
OPPENEER TODD M (US)
PINKSTAFF JASON K (US)
Application Number:
PCT/US2016/065520
Publication Date:
October 26, 2017
Filing Date:
December 08, 2016
Export Citation:
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Assignee:
BIOMARIN PHARM INC (US)
International Classes:
A61K38/22; A61P19/02
Domestic Patent References:
WO2009067639A22009-05-28
Foreign References:
EP1759710A12007-03-07
KR20070017366A2007-02-09
US20100297021A12010-11-25
EP1743653A12007-01-17
Other References:
NICK J. PEAKE ET AL: "Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1[beta] in Cartilage Explants", BIOMACROMOLECULES, vol. 16, no. 2, 9 February 2015 (2015-02-09), pages 524 - 531, XP055376920, ISSN: 1525-7797, DOI: 10.1021/bm501575w
N.J. PEAKE ET AL: "C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 465, no. 4, 1 October 2015 (2015-10-01), AMSTERDAM, NL, pages 784 - 789, XP055376916, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2015.08.087
HÜLYA BÜKÜLMEZ ET AL: "Protective Effects of C-Type Natriuretic Peptide on Linear Growth and Articular Cartilage Integrity in a Mouse Model of Inflammatory Arthritis : C-Type Natriuretic Peptide Protects Cartilage During Arthritis", ARTHRITIS & RHEUMATOLOGY (HOBOKEN), vol. 66, no. 1, 30 December 2013 (2013-12-30), US, pages 78 - 89, XP055376923, ISSN: 2326-5191, DOI: 10.1002/art.38199
Attorney, Agent or Firm:
NEVILLE, Katherine, L. (US)
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