USE OF CALCIUM BINDING PROTEINS TO IMPROVE CARDIAC CONTRACTILE FUNCTION

WIPO Patent Application WO2005003323

A3

Methods useful in the regulation of myocardial contraction are disclosed. The methods are useful in the regulation of heart function. The invention reveals that sorcin overexpression enhances cardiac contractile performance and establishes the concept of sorcin as a regulator of myocardial contractility. The invention also provides screening assays that allow for the identification of agents that modulate sorcin expression. Such agents are useful, for example, for diagnosing cardiac contractile function associated disorders in subjects, and treating the subjects with the agents identified as being able to modulate sorcin expression.

DILLMANN WOLFGANG H (US)
SUAREZ JORGE (US)
BELKE DARRELL (US)
GLOSS BERND (US)

PCT/US2004/022718

August 04, 2005

June 28, 2004

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UNIV CALIFORNIA (US)
DILLMANN WOLFGANG H (US)
SUAREZ JORGE (US)
BELKE DARRELL (US)
GLOSS BERND (US)

A01N63/00; A61K48/00; C12N; (IPC1-7): A01N63/00; A61K48/00

FISCHER A. ET AL: "Overexpression for Sorcin in the Murine Heart Modulates Cardiac.", CIRCULATION., vol. 102, no. 18, October 2000 (2000-10-01), pages 296 - 1448, XP008050149
SUAREZ J. ET AL: "In vivo Adenoviral Gene Transfer of Sorcin Increases Cardiac Contractility Circulation.", vol. 106, no. 19, November 2002 (2002-11-01), pages 29 - 144, XP008050150
SUAREZ J. ET AL: "In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomypathy.", AM.J.PHYSIOL., vol. 286, 2004, pages H68 - H75, XP002988694

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