Title:
USE OF CARBAMATE COMPOUND IN ORDER TO PREVENTATIVELY TREAT HEADACHES
Document Type and Number:
WIPO Patent Application WO/2017/200316
Kind Code:
A1
Abstract:
The present invention a pharmaceutical composition for preventatively treating headaches, containing: a carbamate compound of chemical formula 1 or a pharmaceutically acceptable salt, solvent or hydrate thereof; and a pharmaceutically acceptable carrier. According to the present invention, the pharmaceutical composition can effectively prevent a headache, more specifically, headaches caused by cortical spreading depression, and particularly, chronic headaches including migraines.
Inventors:
SHIN HYE WON (KR)
PARK YOON KYUNG (KR)
PARK YOON KYUNG (KR)
Application Number:
PCT/KR2017/005171
Publication Date:
November 23, 2017
Filing Date:
May 18, 2017
Export Citation:
Assignee:
SK BIOPHARMACEUTICALS CO LTD (KR)
International Classes:
A61K31/41; A61K9/00; A61K9/28; A61K31/16
Domestic Patent References:
| WO2006112685A1 | 2006-10-26 | |||
| WO2010150946A1 | 2010-12-29 | |||
| WO2011046380A2 | 2011-04-21 | |||
| WO2010150946A1 | 2010-12-29 |
Foreign References:
| KR101286499B1 | 2013-07-16 | |||
| US20100323410A1 | 2010-12-23 | |||
| US20110111467A1 | 2011-05-12 | |||
| US3415840A | 1968-12-10 |
Other References:
KARAKURT, A. ET AL.: "Synthesis of Some 1-(2-naphthy1)-2-(imidazole-1-yl) Ethanone Oxime and Oxime ether Derivatives and Their Anticonvulsant and Antimicrobial Activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 5, 2001, pages 421 - 433, XP004372854
KRYMCHANTOWSKI ET AL.: "New and emerging prophylactic agents for migraine", CNS DRUGS, 2002
JACKSON ET AL.: "A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headaches", PLOS ONE, 2015
NOSEDA ET AL.: "Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain.", PAIN, 2013
EDVINSSON ET AL.: "Basic mechanisms of migraine and its acute treatment", PHARMACOL THER., 2012
J.L. JACKSON ET AL.: "A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headaches", PLOS ONE, 2015
AYATA ET AL.: "Suppression of cortical spreading depression in migraine prophylaxis", ANN NEUROL., 2006
MATHEW: "Pathophysiology of chronic migraine and mode of action of preventive medications", HEADACHE, 2011
AKERMAN & GOADSBY: "Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura", NEUROREPORT, 2005
HOFFMANN ET AL.: "Oxcarbazepine does not suppress cortical spreading depression", CEPHALALGIA, 2011
MATHEW, CEPHALALGIA, vol. 13, no. 12, 1993, pages 78 - 83
See also references of EP 3459541A4
KRYMCHANTOWSKI ET AL.: "New and emerging prophylactic agents for migraine", CNS DRUGS, 2002
JACKSON ET AL.: "A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headaches", PLOS ONE, 2015
NOSEDA ET AL.: "Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain.", PAIN, 2013
EDVINSSON ET AL.: "Basic mechanisms of migraine and its acute treatment", PHARMACOL THER., 2012
J.L. JACKSON ET AL.: "A comparative effectiveness meta-analysis of drugs for the prophylaxis of migraine headaches", PLOS ONE, 2015
AYATA ET AL.: "Suppression of cortical spreading depression in migraine prophylaxis", ANN NEUROL., 2006
MATHEW: "Pathophysiology of chronic migraine and mode of action of preventive medications", HEADACHE, 2011
AKERMAN & GOADSBY: "Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura", NEUROREPORT, 2005
HOFFMANN ET AL.: "Oxcarbazepine does not suppress cortical spreading depression", CEPHALALGIA, 2011
MATHEW, CEPHALALGIA, vol. 13, no. 12, 1993, pages 78 - 83
See also references of EP 3459541A4
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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