Title:
USE OF CASQ1-STIM2 BINDING FOR DIAGNOSIS AND PREVENTION OR TREATMENT OF SKELETAL MUSCLE DISEASES CAUSED BY ABNORMAL EXTERNAL CALCIUM INFLUX
Document Type and Number:
WIPO Patent Application WO/2023/090662
Kind Code:
A1
Abstract:
In the present invention, calsequestrin 1 (CASQ1) binds to STIM2 through the C1 (N-terminal 92 amino acid sequence) site of CASQ1 and the expression of CASQ1 or the C1 site thereof (CASQ1-STIM2 binding) is identified to lower store-operated Ca2+ entry (SOCE) and a cytosolic calcium level and increase the level of calcium in the sarcoplasmic reticulum (SR), thereby offering the possibility of diagnosing, preventing, or treating skeletal muscle diseases caused by abnormal external calcium influx.
Inventors:
LEE EUN HUI (KR)
JEONG SEUNG YEON (KR)
CHOI JUN HEE (KR)
JEONG SEUNG YEON (KR)
CHOI JUN HEE (KR)
Application Number:
PCT/KR2022/016018
Publication Date:
May 25, 2023
Filing Date:
October 20, 2022
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K45/06; A61P21/00; G01N33/68
Foreign References:
| KR20210115100A | 2021-09-27 | |||
| KR20190111286A | 2019-10-02 |
Other References:
WOO JIN SEOK, JEONG SEUNG YEON, PARK JI HEE, CHOI JUN HEE, LEE EUN HUI: "Calsequestrin: a well-known but curious protein in skeletal muscle", EXPERIMENTAL AND MOLECULAR MEDICINE, SEOUL, KR, vol. 52, no. 12, 1 December 2020 (2020-12-01), KR , pages 1908 - 1925, XP093067530, ISSN: 1226-3613, DOI: 10.1038/s12276-020-00535-1
MICHELUCCI ANTONIO; GARCíA-CASTAñEDA MARICELA; BONCOMPAGNI SIMONA; DIRKSEN ROBERT T.: "Role of STIM1/ORAI1-mediated store-operated Ca2+entry in skeletal muscle physiology and disease", CELL CALCIUM, ELSEVIER, AMSTERDAM, NL, vol. 76, 30 October 2018 (2018-10-30), AMSTERDAM, NL, pages 101 - 115, XP085550320, ISSN: 0143-4160, DOI: 10.1016/j.ceca.2018.10.004
JEONG SEUNG YEON, OH MI RI, CHOI JUN HEE, WOO JIN SEOK, LEE EUN HUI: "Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle", CELLS, vol. 10, no. 11, pages 2821, XP093067533, DOI: 10.3390/cells10112821
MICHELUCCI ANTONIO; GARCíA-CASTAñEDA MARICELA; BONCOMPAGNI SIMONA; DIRKSEN ROBERT T.: "Role of STIM1/ORAI1-mediated store-operated Ca2+entry in skeletal muscle physiology and disease", CELL CALCIUM, ELSEVIER, AMSTERDAM, NL, vol. 76, 30 October 2018 (2018-10-30), AMSTERDAM, NL, pages 101 - 115, XP085550320, ISSN: 0143-4160, DOI: 10.1016/j.ceca.2018.10.004
JEONG SEUNG YEON, OH MI RI, CHOI JUN HEE, WOO JIN SEOK, LEE EUN HUI: "Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle", CELLS, vol. 10, no. 11, pages 2821, XP093067533, DOI: 10.3390/cells10112821
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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