Title:
USE OF CB-839 IN PREPARATION OF DRUG FOR INHIBITING CORNEAL NEOVASCULARIZATION
Document Type and Number:
WIPO Patent Application WO/2023/169163
Kind Code:
A1
Abstract:
The present invention relates to the technical field of eye drug preparation. Aiming at the problem that complications may be caused by the current prevention and treatment means for corneal neovascularization, the present invention provides a use of CB-839 in the preparation of a drug for inhibiting corneal neovascularization. According to the present invention, a drug loaded with CB-839 can obviously inhibit mouse corneal neovascularization, inflammatory cell infiltration is reduced, obvious side effects are not found, and the defects in the prior art are overcome.
Inventors:
SHI WEIYUN (CN)
ZHOU QINGJUN (CN)
WANG HONGWEI (CN)
ZHANG BINING (CN)
ZHOU QINGJUN (CN)
WANG HONGWEI (CN)
ZHANG BINING (CN)
Application Number:
PCT/CN2023/076103
Publication Date:
September 14, 2023
Filing Date:
February 15, 2023
Export Citation:
Assignee:
INSTITUTE OF OPHTHALMOLOGY AFFILIATED TO SHANDONG FIRST MEDICAL UNIV SHANDONG INSTITUTE OF OPHTHALMO (CN)
International Classes:
A61K31/501; A61K9/06; A61K9/127; A61K47/24; A61K47/28; A61K47/42; A61P27/02
Domestic Patent References:
| WO2022251370A1 | 2022-12-01 | |||
| WO2022001784A1 | 2022-01-06 |
Foreign References:
| CN114917230A | 2022-08-19 | |||
| CN107714650A | 2018-02-23 |
Other References:
HONGLING HUANG, SAAR VANDEKEERE, JOANNA KALUCKA, LAURA BIERHANSL, ANNALISA ZECCHIN, ULRIKE BRüNING, ASJAD VISNAGRI, NADIRA YU: "Role of glutamine and interlinked asparagine metabolism in vessel formation", THE EMBO JOURNAL, vol. 36, no. 16, 15 August 2017 (2017-08-15), pages 2334 - 2352, XP055487330, ISSN: 1460-2075, DOI: 10.15252/embj.201695518
Attorney, Agent or Firm:
QINGDAO ZHONGTIAN HUIZHI INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF: