Title:
USE OF CD38+HLA-DR+CD8+T CELLS IN EARLY DIAGNOSIS OF AGVHD
Document Type and Number:
WIPO Patent Application WO/2024/051675
Kind Code:
A1
Abstract:
Use of CD38 +HLA-DR +CD8 + T cells as a graft-versus-host disease biomarker and use of CD38 +HLA-DR +CD8 + T cells in the preparation of a graft-versus-host disease detection reagent. Compared with healthy volunteers and patients without graft-versus-host disease after transplantation, a patient with acute graft-versus-host disease has a significantly increased proportion of CD38 +HLA-DR +CD8 + T cells in their peripheral blood. ROC curve analysis shows that when CD38 +HLA-DR +CD8 + T cells are used for early diagnosis of acute graft-versus-host disease, the AUC is 1 and the sensitivity and specificity are both up to 100%. Results show that CD38 +HLA-DR +CD8 + T cells are an early marker of acute graft-versus-host disease with a good diagnosis effect and have clinical application value.
Inventors:
LIU YUFENG (CN)
ZHONG LIMEI (CN)
WANG SHUNQING (CN)
MO WENJIAN (CN)
ZHOU RUIQING (CN)
CHEN YINCHUN (CN)
CHEN XIAOWEI (CN)
ZHOU MING (CN)
ZHONG LIMEI (CN)
WANG SHUNQING (CN)
MO WENJIAN (CN)
ZHOU RUIQING (CN)
CHEN YINCHUN (CN)
CHEN XIAOWEI (CN)
ZHOU MING (CN)
Application Number:
PCT/CN2023/116933
Publication Date:
March 14, 2024
Filing Date:
September 05, 2023
Export Citation:
Assignee:
GUANGZHOU FIRST PEOPLES HOSPITAL GUANGZHOU DIGESTIVE DISEASE CENTER GUANGZHOU FIRST PEOPLES HOSPITAL (CN)
International Classes:
G01N33/569
Domestic Patent References:
| WO2014030683A1 | 2014-02-27 |
Foreign References:
| CN115327118A | 2022-11-11 | |||
| US5426028A | 1995-06-20 | |||
| US20210396753A1 | 2021-12-23 | |||
| US20090186017A1 | 2009-07-23 |
Other References:
POOJA, K. ET AL.: "CD38brightCD8+T Cells Associated with the Development of Acute GVHD Are Activated, Proliferating, and Cytotoxic Trafficking Cells", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, vol. 26, no. 1, 20 August 2019 (2019-08-20), XP086034449, ISSN: 1083-8791, DOI: 10.1016/j.bbmt.2019.08.008
CHEN PIN-YUAN, WU CAREN YU-JU, FANG JIAN-HE, CHEN HSIU-CHI, FENG LI-YING, HUANG CHIUNG-YIN, WEI KUO-CHEN, FANG JIA-YOU, LIN CHUN-Y: "Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 10, 9 October 2019 (2019-10-09), Lausanne, CH , XP093148038, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02395
CHEN PIN-YUAN, WU CAREN YU-JU, FANG JIAN-HE, CHEN HSIU-CHI, FENG LI-YING, HUANG CHIUNG-YIN, WEI KUO-CHEN, FANG JIA-YOU, LIN CHUN-Y: "Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 10, 9 October 2019 (2019-10-09), Lausanne, CH , XP093148038, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02395
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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