Title:
USE OF A CINNAMON BARK EXTRACT FOR TREATING AMYLOID-ASSOCIATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2010/041252
Kind Code:
A3
Abstract:
The present application disclosed the use of a cinnamon extract in the treatment of amyloid-associated diseases and disorders, such as Alzheimer's disease.
Inventors:
OVADIA MICHAEL (IL)
GAZIT EHUD (IL)
FRYDMAN-MAROM ANAT (IL)
GAZIT EHUD (IL)
FRYDMAN-MAROM ANAT (IL)
Application Number:
PCT/IL2009/000963
Publication Date:
July 22, 2010
Filing Date:
October 11, 2009
Export Citation:
Assignee:
UNIV RAMOT (IL)
OVADIA MICHAEL (IL)
GAZIT EHUD (IL)
FRYDMAN-MAROM ANAT (IL)
OVADIA MICHAEL (IL)
GAZIT EHUD (IL)
FRYDMAN-MAROM ANAT (IL)
International Classes:
A61K36/54; A61P25/28; A61K129/00
Domestic Patent References:
| WO2005060352A2 | 2005-07-07 | |||
| WO1994018994A1 | 1994-09-01 | |||
| WO2008121412A1 | 2008-10-09 |
Other References:
KIM DARRICK S H L ET AL: "Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult.", JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (NEW YORK, N.Y.) APR 2007 LNKD- PUBMED:17480132, vol. 13, no. 3, April 2007 (2007-04-01), pages 333 - 340, XP002582331, ISSN: 1075-5535
IWASAKI K ET AL: "A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 200409 US LNKD- DOI:10.1111/J.1532-5415.2004.52415.X, vol. 52, no. 9, September 2004 (2004-09-01), pages 1518 - 1521, XP002582332, ISSN: 0002-8614
ANEKONDA ET AL: "Can herbs provide a new generation of drugs for treating Alzheimer's disease?", BRAIN RESEARCH REVIEWS, ELSEVIER, NL, vol. 50, no. 2, 15 December 2005 (2005-12-15), pages 361 - 376, XP005171917, ISSN: 0165-0173
PORAT YAIR ET AL: "Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 67, no. 1, January 2006 (2006-01-01), pages 27 - 37, XP003016012
PETERSON DYLAN W ET AL: "Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro.", JOURNAL OF ALZHEIMER'S DISEASE : JAD JUL 2009 LNKD- PUBMED:19433898, vol. 17, no. 3, July 2009 (2009-07-01), pages 585 - 597, XP009133606, ISSN: 1875-8908
IWASAKI K ET AL: "A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 200409 US LNKD- DOI:10.1111/J.1532-5415.2004.52415.X, vol. 52, no. 9, September 2004 (2004-09-01), pages 1518 - 1521, XP002582332, ISSN: 0002-8614
ANEKONDA ET AL: "Can herbs provide a new generation of drugs for treating Alzheimer's disease?", BRAIN RESEARCH REVIEWS, ELSEVIER, NL, vol. 50, no. 2, 15 December 2005 (2005-12-15), pages 361 - 376, XP005171917, ISSN: 0165-0173
PORAT YAIR ET AL: "Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 67, no. 1, January 2006 (2006-01-01), pages 27 - 37, XP003016012
PETERSON DYLAN W ET AL: "Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro.", JOURNAL OF ALZHEIMER'S DISEASE : JAD JUL 2009 LNKD- PUBMED:19433898, vol. 17, no. 3, July 2009 (2009-07-01), pages 585 - 597, XP009133606, ISSN: 1875-8908
Attorney, Agent or Firm:
REINHOLD COHN AND PARTNERS (61131 Tel Aviv, IL)
Download PDF: