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Title:
USE OF CITRULLINE AND GLUTATHIONE TO INCREASE MUSCLE MASS
Document Type and Number:
WIPO Patent Application WO/2018/221654
Kind Code:
A1
Abstract:
The invention provides citrulline or a salt thereof and glutathione or a salt thereof for use in increasing a ratio of muscle mass to total body weight in a person in conjunction with a resistance workout program, as well as a method of increasing a ratio of muscle mass to total body weight in a person by administering citrulline or a salt thereof and glutathione or a salt thereof to the person in conjunction with a resistance workout program. The citrulline and glutathione or salts thereof are administered daily for a period greater than 7 days, whereas the resistance workout program is administered for at least the entire period during which the two compounds are administered. The muscle mass is measured by a body composition meter.

Inventors:
MORITA Masahiko (1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
KAMIMURA Ayako (1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
WILLOUGHBY, Darryn S. (1312 S. 5th Street, P.O. Box 97313 Waco, Texas, 76798-7313, US)
Application Number:
JP2018/020961
Publication Date:
December 06, 2018
Filing Date:
May 31, 2018
Export Citation:
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Assignee:
KYOWA HAKKO BIO CO., LTD. (1-6-1, Otemachi Chiyoda-k, Tokyo 85, 〒1008185, JP)
International Classes:
A23L33/175; A23L33/18; A61K31/198; A61P21/00
Domestic Patent References:
WO2001028356A22001-04-26
WO2017038991A12017-03-09
Foreign References:
US20150011463A12015-01-08
JP2011245471A2011-12-08
US20080038320A12008-02-14
US20150141514A12015-05-21
Other References:
HWANG P. ET AL.: "Eight weeks of resistance training in conjunction with glutathione and L-citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained males", J. INT. SOC. SPORTS NUTR., vol. 30, 15 January 2018 (2018-01-15), pages 1 - 10, XP055561775
SUZUKI T. ET AL.: "The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 81, no. 2, February 2017 (2017-02-01), pages 372 - 375, XP055561794
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (Toranomon East Bldg. 10F, 7-13 Nishi-Shimbashi 1-chome, Minato-k, Tokyo 03, 〒1050003, JP)
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