Title:
USE OF CO-RELEASING COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO2003066067
Kind Code:
A3
Abstract:
Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g. rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
Inventors:
HAAS WERNER (PT)
ROMAO CARLOS (PT)
ROYO BEATRIZ (PT)
FERNANDES ANA CRISTINA (PT)
GONCALVES ISABEL (PT)
ROMAO CARLOS (PT)
ROYO BEATRIZ (PT)
FERNANDES ANA CRISTINA (PT)
GONCALVES ISABEL (PT)
Application Number:
PCT/IB2003/000932
Publication Date:
February 05, 2004
Filing Date:
February 03, 2003
Export Citation:
Assignee:
HAAS WERNER (PT)
ROMAO CARLOS (PT)
ROYO BEATRIZ (PT)
FERNANDES ANA CRISTINA (PT)
GONCALVES ISABEL (PT)
ROMAO CARLOS (PT)
ROYO BEATRIZ (PT)
FERNANDES ANA CRISTINA (PT)
GONCALVES ISABEL (PT)
International Classes:
A61K31/00; A61K31/18; A61K31/192; A61K31/28; A61K31/555; A61K31/60; A61K31/603; A61K31/616; A61K31/695; A61K31/7048; A61K45/00; A61K31/7135; A61K33/00; A61K33/14; A61K33/32; A61K45/06; A61K47/48; A61P9/00; A61P9/10; A61P11/06; A61P25/28; A61P29/00; C07F11/00; C07F13/00; C07F15/02; C07F17/00; (IPC1-7): A61K31/7048; A61K31/695; A61K31/7135; A61K31/603; A61K31/28; A61K31/60; A61K33/32; A61K33/14; A61P29/00; A61K47/48
Domestic Patent References:
| WO2002092075A2 | 2002-11-21 |
Foreign References:
| US5882674A | 1999-03-16 | |||
| US5086060A | 1992-02-04 |
Other References:
OTTERBEIN LEO E ET AL: "Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.", NATURE MEDICINE, vol. 6, no. 4, April 2000 (2000-04-01), pages 422 - 428, XP002249546, ISSN: 1078-8956
MEDER H-J ET AL: "METALLKOMPLEXE MIT BIOLOGISCH WICHTIGEN LIGANDEN, XLII U1 CARBONYLMETALLKOMPLEXE MIT ANIONEN VON MEHRFUNKTIONELLEN ALPHA- AMINOSAEUREN. METAL COMPLEXES WITH BIOLOGICALLY IMPORTANT LIGANDS, XLII U1 CARBONYL METAL COMPLEXES WITH ANIONS OF POLYFUNCTIONAL ALPHA-AMINO ACIDS", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, VERLAG DER ZEITSCHRIFT FUR NATURFORSCHUNG. TUBINGEN, DE, 1986, pages 1247 - 1254, XP002043521, ISSN: 0932-0776
VERONA I ET AL: "Regioselectivity in the nucleophilic functionalization of dibenzofuran, dibenzothiophene and xanthene complexes of Mn(CO)3", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH, vol. 524, no. 1-2, 1 November 1996 (1996-11-01), pages 71 - 80, XP004217578, ISSN: 0022-328X
MEDER H-J ET AL: "METALLKOMPLEXE MIT BIOLOGISCH WICHTIGEN LIGANDEN, XLII U1 CARBONYLMETALLKOMPLEXE MIT ANIONEN VON MEHRFUNKTIONELLEN ALPHA- AMINOSAEUREN. METAL COMPLEXES WITH BIOLOGICALLY IMPORTANT LIGANDS, XLII U1 CARBONYL METAL COMPLEXES WITH ANIONS OF POLYFUNCTIONAL ALPHA-AMINO ACIDS", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, VERLAG DER ZEITSCHRIFT FUR NATURFORSCHUNG. TUBINGEN, DE, 1986, pages 1247 - 1254, XP002043521, ISSN: 0932-0776
VERONA I ET AL: "Regioselectivity in the nucleophilic functionalization of dibenzofuran, dibenzothiophene and xanthene complexes of Mn(CO)3", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH, vol. 524, no. 1-2, 1 November 1996 (1996-11-01), pages 71 - 80, XP004217578, ISSN: 0022-328X
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