Title:
USE OF COMPOSITION COMPRISING ADIPOSE STEM CELL-DERIVED EXOSOME AS EFFECTIVE INGREDIENT IN IMPROVING RENAL FUNCTION
Document Type and Number:
WIPO Patent Application WO/2019/083201
Kind Code:
A3
Abstract:
The present invention provides a composition comprising an adipose stem cell-derived exosome as an effective ingredient for improving renal function and/or preventing, relieving, alleviating, or treating a renal disease. A composition of the present invention can prevent, relieve, improve, or treat various renal diseases by reducing the production of inflammatory cytokines associated with nephritis or acute kidney injury (AKI) and inflammation-related factors and effectively improving nephrotoxicity-related indices and renal functions.
Inventors:
YI YONG WEON (KR)
CHO BYONG SEUNG (KR)
CHO BYONG SEUNG (KR)
Application Number:
PCT/KR2018/011983
Publication Date:
August 08, 2019
Filing Date:
October 11, 2018
Export Citation:
Assignee:
EXOCOBIO INC (KR)
International Classes:
A61K35/28; A23L33/10; A61K35/51
Foreign References:
| KR20170005854A | 2017-01-16 | |||
| US20170296626A1 | 2017-10-19 | |||
| US20110003008A1 | 2011-01-06 | |||
| KR20160075692A | 2016-06-29 | |||
| KR20150145720A | 2015-12-30 | |||
| KR20160115988A | 2016-10-06 |
Other References:
PETERSEN, K.: "A review of exosome separation techniques and characteri- zation of B16-F10 mouse melanoma exosomes with AF4-UV-MALS-DLS-TEM", ANAL. BIOANAL. CHEM., vol. 406, no. 30, 2014, pages 7855 - 7866, XP035376024
BOSCH, S.: "Trehalose prevents aggregation of exosomes and cryodamage", SCIENTIFIC, 8 November 2016 (2016-11-08), XP055500173
BOSCH, S.: "Trehalose prevents aggregation of exosomes and cryodamage", SCIENTIFIC, 8 November 2016 (2016-11-08), XP055500173
Attorney, Agent or Firm:
LEE, Dong-Ki (KR)
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