Title:
USE OF COMPOSITION COMPRISING STEM CELL-DERIVED EXOSOME AS EFFECTIVE INGREDIENT FOR PREVENTION OR ALLEVIATION OF PRURITUS
Document Type and Number:
WIPO Patent Application WO/2019/004757
Kind Code:
A2
Abstract:
The present invention provides a composition comprising stem cell-derived exosomes as an effective ingredient for prevention, suppression, reduction, alleviation, or treatment of pruritus. Acting on multiple cytokine targets causative of pruritus such as IL-4, IL-31, and TSLP, a composition of the present invention can be applied to a wide spectrum of pruritus attributed to various causes and can effectively suppress and reduce pruritus. In addition, when directly applied to the human skin, the composition of the present invention can remarkably alleviate pruritus-associated clinical indices and erythema. Therefore, the composition of the present invention can be useful as pharmaceutical compositions, skin agents for external use, and cosmetic compositions for preventing, suppressing, reducing, alleviating, or treating pruritus.
Inventors:
YI YONG WEON (KR)
CHO BYONG SEUNG (KR)
CHO BYONG SEUNG (KR)
Application Number:
PCT/KR2018/007369
Publication Date:
January 03, 2019
Filing Date:
June 28, 2018
Export Citation:
Assignee:
EXOCOBIO INC (KR)
International Classes:
A61K35/28; A23L33/10; A61K8/98; A61Q19/00
Other References:
WILSON SR ET AL.: "The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch", CELL, vol. 155, no. 2, 2013, pages 285 - 95, XP028737310, DOI: 10.1016/j.cell.2013.08.057
NATURE REVIEW IMMUNOLOGY, no. 2, 2002, pages 569 - 579
VASILIY S. CHERNYSHEV ET AL.: "Size and shape characterization of hydrated and desiccated exosomes", ANAL BIOANAL CHEM, 2015
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 117, 2001, pages 977 - 983
J ALLERGY CLIN IMMUNOL, vol. 117, 2006, pages 411 - 417
EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 73, 2018, pages 29 - 36
NEW ENGLAND JOURNAL OF MEDICINE, vol. 376, no. 9, 2017, pages 826 - 835
See also references of EP 3646877A4
NATURE REVIEW IMMUNOLOGY, no. 2, 2002, pages 569 - 579
VASILIY S. CHERNYSHEV ET AL.: "Size and shape characterization of hydrated and desiccated exosomes", ANAL BIOANAL CHEM, 2015
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 117, 2001, pages 977 - 983
J ALLERGY CLIN IMMUNOL, vol. 117, 2006, pages 411 - 417
EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 73, 2018, pages 29 - 36
NEW ENGLAND JOURNAL OF MEDICINE, vol. 376, no. 9, 2017, pages 826 - 835
See also references of EP 3646877A4
Attorney, Agent or Firm:
LEE, Dong-Ki (KR)
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