Title:
USE OF COMPOSITION COMPRISING STEM CELL-DERIVED EXOSOME AS EFFECTIVE INGREDIENT IN ALLEVIATING NON-ALCOHOLIC SIMPLE STEATOSIS OR NON-ALCOHOLIC STEATOHEPATITIS
Document Type and Number:
WIPO Patent Application WO/2019/031729
Kind Code:
A3
Abstract:
The present invention provides a composition comprising a stem cell-derived exosome as an effective ingredient for preventing, relieving, alleviating, or treating non-alcoholic simple steatosis or non-alcoholic steatohepatitis. A composition of the present invention can prevent, relieve, alleviate, or treat non-alcoholic simple steatosis or non-alcoholic steatohepatitis by reducing or relieving fat accumulation or inflammation in hepatocytes or liver tissues, which acts as a cause of non-alcoholic simple steatosis or non-alcoholic steatohepatitis and by inducing the histological state of non-alcoholic simple steatosis or non-alcoholic steatohepatitis to moderate, improve, or change for the better.
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Inventors:
YI YONG WEON (KR)
CHO BYONG SEUNG (KR)
CHO BYONG SEUNG (KR)
Application Number:
PCT/KR2018/008325
Publication Date:
May 16, 2019
Filing Date:
July 24, 2018
Export Citation:
Assignee:
EXOCOBIO INC (KR)
International Classes:
A61K35/28; A23L33/10; A61K9/00; A61K35/51
Domestic Patent References:
| WO2016054094A1 | 2016-04-07 |
Foreign References:
| CN106974937A | 2017-07-25 | |||
| KR101501433B1 | 2015-03-11 |
Other References:
LEE, YOUNG-SUN ET AL.: "Exosomes Derived from Palmitic Acid-treated Hepatocytes Induce Fibrotic Activation of Hepatic Stellate Cells", SCIENTIFIC REPORTS, vol. 7, no. 1, 16 June 2017 (2017-06-16), pages 1 - 10, XP055608796, ISSN: 2045-2322, DOI: 10.1038/s41598-017-03389-2
HU , LI ET AL.: "Exosomes Derived from Human Adipose Mensenchymal Stem Cells Accelerates Cutaneous Wound Healing via Optimizing the Characteristics of Fibroblasts", SCIENTIFIC REPORTS, vol. 6, 2016, pages 1 - 1 1, XP055485849, DOI: doi:10.1038/srep32993
HU , LI ET AL.: "Exosomes Derived from Human Adipose Mensenchymal Stem Cells Accelerates Cutaneous Wound Healing via Optimizing the Characteristics of Fibroblasts", SCIENTIFIC REPORTS, vol. 6, 2016, pages 1 - 1 1, XP055485849, DOI: doi:10.1038/srep32993
Attorney, Agent or Firm:
LEE, Dong-Ki (KR)
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