Title:
USE OF COMPOUND IN PREPARATION OF ANTI-INFLAMMATORY DRUG
Document Type and Number:
WIPO Patent Application WO/2023/241140
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biological medicine, particularly to use of a class of substituted diaryl compounds in the preparation of anti-inflammatory drugs. The compounds have a structure represented by formula I. Experimental data shows that the content of IL-6 measured by the compounds of the present invention is less than that of IL-6 in LPS-induced RAW264.7 cells, indicating that the compounds have anti-inflammatory activity to a certain extent. When CHJ04022R is at 0.5 μM, 1.0 μM, and 2.0 μM, the contents of inflammatory factors IL-23, IL-1α, IFN-γ, TNF-α, MCP-1, IL-1β, IL-6, IL-17A, IFN-β, and GM-CSF can be reduced, so the compound has better anti-inflammatory activity than that of dexamethasone.
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Inventors:
LIU BO (CN)
YAO QINGQIANG (CN)
JIE WEILIN (CN)
CHEN HAIJIAO (CN)
YANG XINMEI (CN)
LI YAN (CN)
LI YING (CN)
ZHI YING (CN)
WANG HAIYANG (CN)
ZHAO XIAODONG (CN)
ZHANG FEIPENG (CN)
QU ZHIQIANG (CN)
CAO BENLONG (CN)
YAO QINGQIANG (CN)
JIE WEILIN (CN)
CHEN HAIJIAO (CN)
YANG XINMEI (CN)
LI YAN (CN)
LI YING (CN)
ZHI YING (CN)
WANG HAIYANG (CN)
ZHAO XIAODONG (CN)
ZHANG FEIPENG (CN)
QU ZHIQIANG (CN)
CAO BENLONG (CN)
Application Number:
PCT/CN2023/081547
Publication Date:
December 21, 2023
Filing Date:
March 15, 2023
Export Citation:
Assignee:
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACAD OF MEDICAL SCIENCES (CN)
International Classes:
A61K31/445; A61K31/138; A61K31/40; A61K31/4164; A61P29/00; C07C217/20; C07D211/14; C07D233/60; C07D295/088
Foreign References:
| CN114848640A | 2022-08-05 | |||
| CN113387872A | 2021-09-14 | |||
| CN113387873A | 2021-09-14 |
Other References:
GENG SHUANGSHUANG, CHEN HAIJIAO, LI YAN, LI YING, PANG JINGXIANG, ZHANG FEIPENG, QU ZHIQIANG, LI MENGJUN, LIU NA, YAO QINGQIANG, M: "Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors", MOLECULES, MDPI AG, CH, vol. 27, no. 6, 21 March 2022 (2022-03-21), CH , pages 2020, XP093117012, ISSN: 1420-3049, DOI: 10.3390/molecules27062020
YAN-HONG BU, WU HONG; SUN MING-HUI; ZHANG HENG; DAI XUE-JING: "Role of sphingosine-1-phosphate and its signaling pathway in inflammation-related diseases ", CHINESE PHARMACOLOGICAL BULLETIN, vol. 35, no. 8, 31 July 2019 (2019-07-31), pages 1041 - 1046, XP093117027
YAN-HONG BU, WU HONG; SUN MING-HUI; ZHANG HENG; DAI XUE-JING: "Role of sphingosine-1-phosphate and its signaling pathway in inflammation-related diseases ", CHINESE PHARMACOLOGICAL BULLETIN, vol. 35, no. 8, 31 July 2019 (2019-07-31), pages 1041 - 1046, XP093117027
Attorney, Agent or Firm:
BEIJING ZHCC INTELLECTUAL PROPERTY CO., LTD. (CN)
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