Title:
USE OF COMPOUND KYA1797K IN PREPARATION OF ANTI-HBV VIRAL DRUG
Document Type and Number:
WIPO Patent Application WO/2023/044967
Kind Code:
A1
Abstract:
Provided is the use of a compound KYA1797K in the preparation of an anti-HBV viral drug. The anti-viral effect, particularly the anti-HBV effect, of the compound KYA1797K is found. Experiments show that the small molecule KYA1797K can inhibit the replication of HBV on the cellular level and the replication of HBV in mice. The small molecule can be used as a potential clinical trial drug for treating HBV infection and related diseases, and is expected to become a new treatment means, thereby prolonging the survival period of a patient and improving the survival quality of a patient.
Inventors:
ZENG MUSHENG (CN)
DAI DANLING (CN)
WEN SHIJUN (CN)
ZHONG QIAN (CN)
FENG GUOKAI (CN)
ZHANG XIAOYONG (CN)
XIE CHU (CN)
DAI DANLING (CN)
WEN SHIJUN (CN)
ZHONG QIAN (CN)
FENG GUOKAI (CN)
ZHANG XIAOYONG (CN)
XIE CHU (CN)
Application Number:
PCT/CN2021/122653
Publication Date:
March 30, 2023
Filing Date:
October 08, 2021
Export Citation:
Assignee:
SUN YAT SEN UNIV CANCER CENTER SYSUCC (CN)
International Classes:
A61K31/427; A61P1/16; A61P31/20
Foreign References:
| US10624949B1 | 2020-04-21 | |||
| US20160263131A1 | 2016-09-15 |
Other References:
HARRISON KELLY S.; JONES CLINTON: "Wnt antagonists suppress herpes simplex virus type 1 productive infection", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 191, 5 May 2021 (2021-05-05), NL , XP086637097, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2021.105082
VON OLSHAUSEN GESA, QUASDORFF MARIA, BESTER ROMINA, ARZBERGER SILKE, KO CHUNKYU, VAN DE KLUNDERT MAARTEN, ZHANG KE, ODENTHAL MARGA: "Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, vol. 9, no. 74, 21 September 2018 (2018-09-21), United States , pages 33947 - 33960, XP093051261, ISSN: 1949-2553, DOI: 10.18632/oncotarget.26103
LEVRERO M: "Viral hepatitis and liver cancer: the case of hepatitis C", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 25, no. 27, 26 June 2006 (2006-06-26), London , pages 3834 - 3847, XP037742483, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1209562
YANG HUI-LING, LIU XIAO-JING; QIN LI-JUN; YE FENG; ZHANG XI: "Study on the effect of Hepatitis B virus infection on the Wnt/ β-catenin signaling pathway", ZHONG HUA YI YUAN GAN RAN XUE ZA ZHI= CHINESE JOURNAL OF NOSOCOMICOLOGY, XX, CN, vol. 30, no. 7, 1 January 2020 (2020-01-01), CN , pages 976 - 980, XP093051262, ISSN: 1005-4529, DOI: 10.11816/cn.ni.2020-191177
XIE LIANGHAI, JIANG HAN; WU FUSHENG: "Role of Wnt/β-catenin signaling pathway in promoting tumorigenesis of hepatocellular carcinoma", JOURNAL OF SOUTHERN MEDICAL UNIVERSITY - NAN FANG YI KE DA XUEBAO, NANFANG-YIKE-DAXUE GUANGZHOU, CN, vol. 34, no. 6, 1 June 2014 (2014-06-01), CN , pages 913 - 916, XP093051263, ISSN: 1673-4254, DOI: 10.3969/j.issn.1673-4254.2014.06.32
VON OLSHAUSEN GESA, QUASDORFF MARIA, BESTER ROMINA, ARZBERGER SILKE, KO CHUNKYU, VAN DE KLUNDERT MAARTEN, ZHANG KE, ODENTHAL MARGA: "Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, vol. 9, no. 74, 21 September 2018 (2018-09-21), United States , pages 33947 - 33960, XP093051261, ISSN: 1949-2553, DOI: 10.18632/oncotarget.26103
LEVRERO M: "Viral hepatitis and liver cancer: the case of hepatitis C", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 25, no. 27, 26 June 2006 (2006-06-26), London , pages 3834 - 3847, XP037742483, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1209562
YANG HUI-LING, LIU XIAO-JING; QIN LI-JUN; YE FENG; ZHANG XI: "Study on the effect of Hepatitis B virus infection on the Wnt/ β-catenin signaling pathway", ZHONG HUA YI YUAN GAN RAN XUE ZA ZHI= CHINESE JOURNAL OF NOSOCOMICOLOGY, XX, CN, vol. 30, no. 7, 1 January 2020 (2020-01-01), CN , pages 976 - 980, XP093051262, ISSN: 1005-4529, DOI: 10.11816/cn.ni.2020-191177
XIE LIANGHAI, JIANG HAN; WU FUSHENG: "Role of Wnt/β-catenin signaling pathway in promoting tumorigenesis of hepatocellular carcinoma", JOURNAL OF SOUTHERN MEDICAL UNIVERSITY - NAN FANG YI KE DA XUEBAO, NANFANG-YIKE-DAXUE GUANGZHOU, CN, vol. 34, no. 6, 1 June 2014 (2014-06-01), CN , pages 913 - 916, XP093051263, ISSN: 1673-4254, DOI: 10.3969/j.issn.1673-4254.2014.06.32
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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