Title:
USE OF COMPOUND SS-31 IN PREPARATION OF DRUG OR PREPARATION FOR TREATING ATHEROSCLEROSIS AND RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2018/171279
Kind Code:
A1
Abstract:
Disclosed is the use of compound Szeto-Schiller-31 (SS-31) in the preparation of a drug for treating atherosclerosis and related diseases, such as carotid stenosis, lower extremity arteriosclerosis obliterans and coronary heart disease. Through experiments, it has been found that SS-31 reduces the degree of atherosclerosis, wherein same: significantly decreases the level of arterial ROS in mice, reduces oxidative damage, and promotes the ATP level; significantly reduces the content of macrophages at atherosclerotic plaques, significantly increases the content of smooth muscle cells and collagen content at the plaques, and stabilizes the atherosclerotic plaques; significantly improves the inflammation level; and significantly decreases the expression of the lipid-uptaking protein at aortic plaques. The results show that SS-31 plays a role in the treatment of atherosclerotic diseases and diseases related thereto.
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Inventors:
LI KUANYU (CN)
QIAO TONG (CN)
QIAO TONG (CN)
Application Number:
PCT/CN2017/118835
Publication Date:
September 27, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
UNIV NANJING (CN)
International Classes:
A61K38/07; A61P9/10
Domestic Patent References:
| WO2016007921A1 | 2016-01-14 |
Foreign References:
| CN107041946A | 2017-08-15 | |||
| CN104324360A | 2015-02-04 | |||
| CN1938042A | 2007-03-28 | |||
| CN104203262A | 2014-12-10 | |||
| CN102791279A | 2012-11-21 |
Other References:
ZHANG, MENG: "Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet", PLOS ONE, vol. 12A, no. 9, e0185688, 29 September 2017 (2017-09-29), pages 1 - 15, XP055610654
HAO, SHUANGYING: "Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidi- zed Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells", MOLECULES, vol. 20, no. 12, 1 December 2015 (2015-12-01), XP055610656
HAO, SHUANGYING: "Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidi- zed Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells", MOLECULES, vol. 20, no. 12, 1 December 2015 (2015-12-01), XP055610656
Attorney, Agent or Firm:
JIANGSU YINCHUANG LAW FIRM (CN)
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