Title:
USE OF COMPOUNDS ISOLATED FROM MORUS BARK
Document Type and Number:
WIPO Patent Application WO/2014/168458
Kind Code:
A1
Abstract:
The present invention relates to pharmaceutical composition for the prevention and treatment of diabetic complications, or health food, comprising Cathayanin B or Kuwanol A isolated from Morus Bark. The compound Cathayanin B according to the present invention is isolated from Morus Bark and inhibits the formation of advanced glycation end-products (AGEs), which cause diabetic complications, and inhibits aldose reductase activity. Kuwanol A, another compound isolated from Morus Bark, inhibits TGF-β1 signaling. Therefore, the pharmaceutical composition or health food comprising Cathayanin B or Kuwanol A according to the present invention can be used to inhibit diabetic nephritis, diabetic retinopathy, and diabetic neuropathy, which are diabetic complications. In particular, Kuwanol A can also be used for pharmaceutical composition for the prevention and treatment of various fibrosis and metastasis conditions as well as health food to improve said conditions.
Inventors:
CHANG HWAN BONG (KR)
YOON JOOBYOUNG (KR)
LEE HYUNYONG (KR)
RHO YANG KOOK (KR)
YOON JOOBYOUNG (KR)
LEE HYUNYONG (KR)
RHO YANG KOOK (KR)
Application Number:
PCT/KR2014/003163
Publication Date:
October 16, 2014
Filing Date:
April 11, 2014
Export Citation:
Assignee:
DONG WHA PHARM CO LTD (KR)
International Classes:
A61K31/05; A61K31/045; A61K36/605; A61P3/10
Domestic Patent References:
| WO2012134126A2 | 2012-10-04 |
Foreign References:
| US20100166898A1 | 2010-07-01 |
Other References:
NI, G. ET AL.: "Chemical constituents of the stem bark of Morus cathayana", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, vol. 12, no. 6, 2010, pages 505 - 515
BAJAJ, Y. P. S. ET AL.: "Morus species (Mulberry): In vitro culture, micropropagation, and the formation of mulberrofuran, Kuwanol, and other secondary metabolites", BIOTECHNOLOGY IN AGRICULTURE AND FORESTRY, vol. 41, 1998, pages 261 - 285
HAMDY, S. M.: "Effect of Morus alba Linn extract on enzymatic activities in diabetic rats", JOURNAL OF APPLIED SCIENCES RESEARCH, vol. 8, no. 1, 2012, pages 10 - 16
BAJAJ, Y. P. S. ET AL.: "Morus species (Mulberry): In vitro culture, micropropagation, and the formation of mulberrofuran, Kuwanol, and other secondary metabolites", BIOTECHNOLOGY IN AGRICULTURE AND FORESTRY, vol. 41, 1998, pages 261 - 285
HAMDY, S. M.: "Effect of Morus alba Linn extract on enzymatic activities in diabetic rats", JOURNAL OF APPLIED SCIENCES RESEARCH, vol. 8, no. 1, 2012, pages 10 - 16
Attorney, Agent or Firm:
ROH, Jae-Chull (4F 30 ,25-gil, Teheran-ro,Gangnam-gu, Seoul 135-909, KR)
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