Title:
USE OF COPPER CHELATORS TO INHIBIT THE INACTIVATION OF PROTEIN C
Document Type and Number:
WIPO Patent Application WO2003007686
Kind Code:
A3
Abstract:
The present invention is based on the unexpected discovery that activated protein C (APC) is inactivated by copper. Accordingly, the invention provides improved methods of treating diseases and conditions treatable with APC which utilize a copper chelator to inhibit the inactivation of APC by copper.
Inventors:
BAR-OR DAVID
YUKL RICHARD L
YUKL RICHARD L
Application Number:
PCT/US2002/022951
Publication Date:
November 06, 2003
Filing Date:
July 19, 2002
Export Citation:
Assignee:
DMI BIOSCIENCES INC (US)
International Classes:
A61K38/00; A61K47/42; A61K38/48; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/02; A61P19/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P35/04; A61P37/06; A61P41/00; A61P43/00; C07K5/02; C07K5/06; C07K5/083; C07K5/103; C07K5/113; C07K7/06; C12N9/64; (IPC1-7): A61K38/16
Foreign References:
| US6017888A | 2000-01-25 | |||
| US6162629A | 2000-12-19 |
Other References:
See also references of EP 1417055A4
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