Title:
USE OF CXCL6 CHEMOKINE IN THE PREVENTION OR REPAIR OF CARTILAGE DEFECTS
Document Type and Number:
WIPO Patent Application WO2005014026
Kind Code:
A3
Abstract:
The present invention disclosed the expression of CXCL6 by cells which are able to form stable cartilage. The invention describes the use of these cells and of CXCL6 to promote cartilage (and underlying bone) formation e.g. in the repair of cartilage or osteochondral defects. The invention further describes the use of chemokines in the modulation of progenitor cell differentiation.
Inventors:
LUYTEN FRANK (BE)
DE BARI COSIMO (GB)
DELL ACCIO FRANCESCO (GB)
DE BARI COSIMO (GB)
DELL ACCIO FRANCESCO (GB)
Application Number:
PCT/BE2004/000117
Publication Date:
March 17, 2005
Filing Date:
August 12, 2004
Export Citation:
Assignee:
TIGENIX NV (BE)
LUYTEN FRANK (BE)
DE BARI COSIMO (GB)
DELL ACCIO FRANCESCO (GB)
LUYTEN FRANK (BE)
DE BARI COSIMO (GB)
DELL ACCIO FRANCESCO (GB)
International Classes:
A61K35/32; A61K38/19; A61P19/00; (IPC1-7): A61K38/19; A61P19/00
Foreign References:
| US5786217A | 1998-07-28 | |||
| US6410268B1 | 2002-06-25 | |||
| EP1312614A1 | 2003-05-21 | |||
| US20020123483A1 | 2002-09-05 | |||
| US6413511B1 | 2002-07-02 |
Other References:
WUYTS ANJA ET AL: "The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: Comparison with interleukin-8/CXCL8.", LABORATORY INVESTIGATION, vol. 83, no. 1, January 2003 (2003-01-01), pages 23 - 34, XP002314496, ISSN: 0023-6837
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