Title:
USE OF D-ENANTIOMERIC PEPTIDE LIGANDS OF MONOMERIC α-SYNUCLEIN FOR THE THERAPY OF VARIOUS SYNUCLEINOPATHIES
Document Type and Number:
WIPO Patent Application WO/2022/200327
Kind Code:
A3
Abstract:
The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6 or SEQ ID NO: 7, as well as to such a peptide for using in the treatment of synucleinopathies.
Inventors:
WILLBOLD DIETER (DE)
MOHRLÜDER JEANNINE (DE)
SEVENICH MARC (DE)
ALTENDORF TIM (DE)
SANTUR KAROLINE BIANKA (DE)
MOHRLÜDER JEANNINE (DE)
SEVENICH MARC (DE)
ALTENDORF TIM (DE)
SANTUR KAROLINE BIANKA (DE)
Application Number:
PCT/EP2022/057456
Publication Date:
November 17, 2022
Filing Date:
March 22, 2022
Export Citation:
Assignee:
FORSCHUNGSZENTRUM JUELICH GMBH (DE)
International Classes:
A61K38/10; A61P25/28
Other References:
RONIT SHALTIEL-KARYO ET AL: "Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies", PLOS ONE, vol. 5, no. 11, 10 November 2010 (2010-11-10), pages e13863, XP055243084, DOI: 10.1371/journal.pone.0013863
WILLBOLD D ET AL: "1076: Identification and characterization of anti-prionic compounds that disassemble ?Syn prions as a novel therapeutic approach for synucleinopathies", vol. 35, no. SUPPL 1, 1 September 2020 (2020-09-01), pages S489, XP009536370, ISSN: 1531-8257, Retrieved from the Internet
WILLBOLD D ET AL: "1076: Identification and characterization of anti-prionic compounds that disassemble ?Syn prions as a novel therapeutic approach for synucleinopathies", vol. 35, no. SUPPL 1, 1 September 2020 (2020-09-01), pages S489, XP009536370, ISSN: 1531-8257, Retrieved from the Internet
Attorney, Agent or Firm:
RUPPRECHT, Kay (DE)
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