Title:
USE OF DIACEREIN IN PREPARATION OF ANTIVIRAL DRUGS AND TREATMENT OF VIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2020/114444
Kind Code:
A1
Abstract:
Pharmaceutical use of diacerein. Experiments show that diacerein can effectively inhibit hepadnavirus, retrovirus, enterovirus, orthomyxovirus, filovirus, reovirus, arenavirus, hepatitis E virus, astrovirus, orbivirus, coronavirus, parvovirus, adenovirus, polyomavirus, herpes virus, poxvirus, human papilloma virus, paramyxovirus, flavivirus, alphavirus, and rhabdovirus.
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Inventors:
ZHU SHUIFANG (CN)
CONG HAOLONG (CN)
WANG CHENGUANG (CN)
TIAN ZHIQING (CN)
JIANG FAN (CN)
CONG HAOLONG (CN)
WANG CHENGUANG (CN)
TIAN ZHIQING (CN)
JIANG FAN (CN)
Application Number:
PCT/CN2019/123209
Publication Date:
June 11, 2020
Filing Date:
December 05, 2019
Export Citation:
Assignee:
CHINA INSPECTION SCIENCE PHARMACEUTICAL BEIJING GROUP CO LTD (CN)
International Classes:
A61K31/122; A61K31/222; A61K31/192; A61P31/12
Domestic Patent References:
| WO2017192940A1 | 2017-11-09 | |||
| WO2018017426A1 | 2018-01-25 | |||
| WO2007139150A1 | 2007-12-06 |
Foreign References:
| CN107921013A | 2018-04-17 | |||
| CN106344549A | 2017-01-25 | |||
| US6686393B1 | 2004-02-03 | |||
| CN105456302A | 2016-04-06 | |||
| CN1985898A | 2007-06-27 |
Other References:
YHANG, CHEN: "Effect of rhein combined with heptodin on HBV reverse transcriptase activity", CHINESE JOURNAL OF PUBLIC HEALTH, vol. 31, no. 6, 30 June 2015 (2015-06-30), DOI: 20200226180632X
QIAN-WEN WANG ET AL: "Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways", PLOS ONE, vol. 13, no. 1, 31 January 2018 (2018-01-31), pages 1 - 19, XP055713114, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191793
SHU-JEN CHANG ET AL: "Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus", ARCHIVES OF PHARMACAL RESEARCH, vol. 37, no. 9, 7 January 2014 (2014-01-07), pages 1117 - 1123, XP037069035, DOI: 10.1007/s12272-013-0325-x
QIAN-WEN WANG ET AL: "Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways", PLOS ONE, vol. 13, no. 1, 31 January 2018 (2018-01-31), pages 1 - 19, XP055713114, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191793
SHU-JEN CHANG ET AL: "Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus", ARCHIVES OF PHARMACAL RESEARCH, vol. 37, no. 9, 7 January 2014 (2014-01-07), pages 1117 - 1123, XP037069035, DOI: 10.1007/s12272-013-0325-x
Attorney, Agent or Firm:
HAIHONG JIACHENG INTELLECTUAL PROPERTY & PARTNERS (CN)
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