Title:
USE OF DINUCLEOSIDE POLYPHOSPHATE TO STIMULATE REMOVAL OF FLUID IN RETINAL DISORDERS
Document Type and Number:
WIPO Patent Application WO2002060454
Kind Code:
B1
Abstract:
The present invention provides a method of treating edematous retinal disorders. The method comprised administration of a pharmaceutical composition comprising a P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from the subretinal and retinal spaces and thereby reduce the accumulation of said fluid associated with retinal detachment and retinal edema. The P2Y receptor agonist may be administered with therapeutic and adjuvant agents commonly used to treat edematous retinal disorders. The pharmaceutical compostion useful in this invention comprises a P2Y receptor agonist with enhanced resistance to extracellular hydrolysis, such as dinucleoside polyphosphate compounds.
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Inventors:
PETERSON WARD M (US)
YERXA BENJAMIN R (US)
YERXA BENJAMIN R (US)
Application Number:
PCT/US2002/003934
Publication Date:
February 13, 2003
Filing Date:
January 29, 2002
Export Citation:
Assignee:
INSPIRE PHARMACEUTICALS INC (US)
PETERSON WARD M (US)
YERXA BENJAMIN R (US)
PETERSON WARD M (US)
YERXA BENJAMIN R (US)
International Classes:
C07H21/04; A61K9/10; A61K9/16; A61K31/7084; A61K31/7125; A61K45/00; A61K47/32; A61K47/34; A61K47/36; A61K47/44; A61P9/10; A61P27/02; C07H19/04; C07H19/20; C07H21/00; (IPC1-7): A61K31/7084; A61K31/70; A61P27/02; C07H19/207
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