Title:
USE OF DNMT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/160127
Kind Code:
A1
Abstract:
[Problem] To provide, as a therapeutic or prophylactic agent for ATL, a compound which replaces injections ("Vidaza (registered trademark)" or "Dacogen (registered trademark)") clinically used as a therapeutic agent for high risk myelodysplastic syndromes or acute myeloid leukemia, has high stability against cytidine deaminase, a metabolic hydrolase, is absorbed in the body even by means of oral administration, and has an effect of inhibiting DNA methyltransferase (DNMT) by being incorporated into a nucleic acid biosynthesis route. [Solution] Provided is a prophylactic/therapeutic agent for ATL, the agent containing a compound represented by formula (I) or a salt thereof (in the formula, R is an OR3 group or a hydrogen atom, R1, R2, and R3 are each a hydrogen atom or a silyl group represented by formula (II) (in the formula, R4, R5, and R6 are each an alkyl group, an aryl group, or an arylalkyl group which may have a substituent); however, the case where R1, R2, and R3 are all a hydrogen atom is excluded).
Inventors:
SAKO MAGOICHI (JP)
SUGIYAMA SHIMPEI (JP)
KURAHASHI YUKI (JP)
WAKITA HIROO (JP)
KIMURA SHINYA (JP)
WATANABE TATSURO (JP)
URESHINO HIROSHI (JP)
SUGIYAMA SHIMPEI (JP)
KURAHASHI YUKI (JP)
WAKITA HIROO (JP)
KIMURA SHINYA (JP)
WATANABE TATSURO (JP)
URESHINO HIROSHI (JP)
Application Number:
PCT/JP2019/005722
Publication Date:
August 22, 2019
Filing Date:
February 16, 2019
Export Citation:
Assignee:
OHARA PHARMACEUTICAL CO LTD (JP)
UNIV SAGA (JP)
UNIV SAGA (JP)
International Classes:
A61K31/706; A61P35/02; A61P43/00; C07F7/18
Domestic Patent References:
| WO2017183217A1 | 2017-10-26 |
Foreign References:
| JP2017531639A | 2017-10-26 |
Other References:
UENOGAWA, KUMI ET AL.: "Azacitidine induces demethylation of pl6INK4a and inhibits growth in adult T- cell leukemia/lymphoma", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, no. 5, November 2011 (2011-11-01), pages 835 - 839, XP055634576
YAN, PENGRONG ET AL.: "Human T- cell Leukemia Virus Type I-Mediated Repression of PDZ-LIM Domain-Containing Protein 2 Involves DNA Methylation But Independent of the Viral Oncoprotein Tax", NEOPLASIA, vol. 11, no. 10, October 2009 (2009-10-01), pages 1036 - 1041, XP055634577
YANG, YANG ET AL.: "Methylation analysis of the adenomatous polyposis coli(APC) gene in adult T- cell leukemia/lymphoma", LEUKEMIA RESEARCH, vol. 29, 2005, pages 47 - 51, XP004639366, doi:10.1016/j.leukres.2004.05.004
TANIGUCHI,AYUO ET AL.: "Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T- cell leukemia", INT. J. CANCER, vol. 123, no. 8, 15 October 2008 (2008-10-15), pages 1824 - 1831, XP055634579
YAN, PENGRONG ET AL.: "Human T- cell Leukemia Virus Type I-Mediated Repression of PDZ-LIM Domain-Containing Protein 2 Involves DNA Methylation But Independent of the Viral Oncoprotein Tax", NEOPLASIA, vol. 11, no. 10, October 2009 (2009-10-01), pages 1036 - 1041, XP055634577
YANG, YANG ET AL.: "Methylation analysis of the adenomatous polyposis coli(APC) gene in adult T- cell leukemia/lymphoma", LEUKEMIA RESEARCH, vol. 29, 2005, pages 47 - 51, XP004639366, doi:10.1016/j.leukres.2004.05.004
TANIGUCHI,AYUO ET AL.: "Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T- cell leukemia", INT. J. CANCER, vol. 123, no. 8, 15 October 2008 (2008-10-15), pages 1824 - 1831, XP055634579
Attorney, Agent or Firm:
SHA Takuho (JP)
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