Title:
USE OF DOXYCYCLINE IN THE PREPARATION OF MEDICINE FOR TREATING OR PREVENTING AGING DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/215602
Kind Code:
A1
Abstract:
Provided in the present invention is a use of doxycycline in the preparation of a medicine for treating or preventing aging diseases, wherein the doxycycline is administered at a dose of less than 2 μg/ml, and the aging diseases mainly comprise skin aging, neurodegenerative diseases, type 2 diabetes, mitochondrial diseases, and cardiovascular diseases caused by hyperlipidemia and hypercholesterolemia, such as atherosclerosis, coronary heart disease, etc.
Inventors:
WEI CHIJU (CN)
LIN HAOPENG (CN)
WANG NA (CN)
PAN FENG (CN)
ZHENG DEJIN (CN)
LIN HAOPENG (CN)
WANG NA (CN)
PAN FENG (CN)
ZHENG DEJIN (CN)
Application Number:
PCT/CN2017/088195
Publication Date:
December 21, 2017
Filing Date:
June 14, 2017
Export Citation:
Assignee:
UNIV SHANTOU (CN)
International Classes:
A61K31/65; A61P3/10; A61P5/50; A61P9/10; A61P17/00; A61P25/00
Foreign References:
| CN105998037A | 2016-10-12 |
Other References:
CHEN, WEI ET AL.: "Advances in Pharmacological Actions and Mechanism of Doxycycline in the Inhibition of Matrix Metalloproteinase", CHINA PHARMACIST, vol. 18, no. 3, 31 December 2015 (2015-12-31), pages 482 - 484, ISSN: 1008-049X
LIU, YUEHENG ET AL.: "Research Progress of Matrix Metalloproteinase-1 and Skin Aging", CHINESE JOURNAL OF GERONTOLOGY, vol. 30, 31 October 2010 (2010-10-31), pages 3037 - 3039, ISSN: 1005-9202
LIU, HAIXIA ET AL.: "Regulated Human Proinsulin Expression in Vivo Using Tet-Inducible Vectors", JOURNAL OF DALIAN MEDICAL UNIVERSITY, vol. 33, no. 5, 31 October 2011 (2011-10-31), pages 444 - 447, ISSN: 1671-7295
LIU, YUEHENG ET AL.: "Research Progress of Matrix Metalloproteinase-1 and Skin Aging", CHINESE JOURNAL OF GERONTOLOGY, vol. 30, 31 October 2010 (2010-10-31), pages 3037 - 3039, ISSN: 1005-9202
LIU, HAIXIA ET AL.: "Regulated Human Proinsulin Expression in Vivo Using Tet-Inducible Vectors", JOURNAL OF DALIAN MEDICAL UNIVERSITY, vol. 33, no. 5, 31 October 2011 (2011-10-31), pages 444 - 447, ISSN: 1671-7295
Attorney, Agent or Firm:
SCIHEAD PATENT AGENT CO., LTD (CN)
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