Title:
USE OF ELECTRONIC OLFACTORY DEVICE IN ON-LINE DETECTION OF CYCLOHEXANECARBOXYLIC ACID CONCENTRATION DURING DOLOMYCIN FERMENTATION
Document Type and Number:
WIPO Patent Application WO/2017/084064
Kind Code:
A1
Abstract:
Provided is a use of an electronic olfactory device in on-line detection of a cyclohexanecarboxylic acid concentration during dolomycin fermentation. An optimization method for supplementing a precursor during the dolomycin fermentation is determined. Namely, the cyclohexanecarboxylic acid in the fermentation broth is maintained at the optimum concentration by means of on-line detection and feedback of the supplementary addition amount of the precursor substance of cyclohexanecarboxylic acid using the electronic olfactory device, not only satisfying the amount of the precursor required for the bacterial synthesis of doramectin, but also not adversely affecting the metabolic activity of the bacteria. This method makes up for the shortcomings where sampling during the process to perform liquid chromatography or gas chromatography is time-consuming and where it is difficult to achieve on-line detection and timely control.
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Inventors:
LING QINGYUN (CN)
LI LIN (CN)
ZHANG YIWEN (CN)
LI LIN (CN)
ZHANG YIWEN (CN)
Application Number:
PCT/CN2015/094996
Publication Date:
May 26, 2017
Filing Date:
November 19, 2015
Export Citation:
Assignee:
JIANGSU WEI LING BIOCHEMICAL TECH CO LTD (CN)
International Classes:
G01N27/12; C12P17/18; C12R1/465
Foreign References:
| CN1346982A | 2002-05-01 | |||
| CN104561180A | 2015-04-29 | |||
| CN102353798A | 2012-02-15 | |||
| CN103454335A | 2013-12-18 | |||
| CN104833708A | 2015-08-12 | |||
| CN105277595A | 2016-01-27 |
Attorney, Agent or Firm:
HUAIAN KEWEN INTEELLECTUAL PROPERTY OFFICE (CN)
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