Title:
USE OF EP4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NASH-ASSOCIATED LIVER CANCER
Document Type and Number:
WIPO Patent Application WO/2018/084230
Kind Code:
A1
Abstract:
This invention is directed to prostaglandin E2 receptor 4 (EP4) antagonists useful in the treatment of nonalcoholic steatohepatitis (NASH)-associated liver cancer in a human or animal. The method comprises administering one or more of Compound A, Compound B or Compound C, or pharmaceutically acceptable salts thereof, as the EP4 antagonist(s). The method may include a pharmaceutical composition comprising the EP4 antagonist(s), and may include one or more other active agents and/or therapies.
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Inventors:
OHTANI NAOKO (JP)
KAMACHI FUMITAKA (JP)
LOO TZE MUN (JP)
KOIZUMI SHINICHI (JP)
OKUMURA TAKAKO (JP)
KAMACHI FUMITAKA (JP)
LOO TZE MUN (JP)
KOIZUMI SHINICHI (JP)
OKUMURA TAKAKO (JP)
Application Number:
PCT/JP2017/039680
Publication Date:
May 11, 2018
Filing Date:
November 02, 2017
Export Citation:
Assignee:
ASKAT INC (JP)
International Classes:
A61K45/06; A61K31/192; A61K31/44; A61K31/64; A61P35/00
Domestic Patent References:
| WO2013040316A1 | 2013-03-21 | |||
| WO2015179615A1 | 2015-11-26 | |||
| WO2015179615A1 | 2015-11-26 | |||
| WO2005021508A1 | 2005-03-10 |
Foreign References:
| US8921391B2 | 2014-12-30 | |||
| US20150004175A1 | 2015-01-01 | |||
| US7029674B2 | 2006-04-18 | |||
| US7488802B2 | 2009-02-10 | |||
| US7521051B2 | 2009-04-21 | |||
| US8008449B2 | 2011-08-30 | |||
| US8354509B2 | 2013-01-15 | |||
| US8617546B2 | 2013-12-31 | |||
| US8709417B2 | 2014-04-29 | |||
| US8217149B2 | 2012-07-10 | |||
| US8383796B2 | 2013-02-26 | |||
| US8552154B2 | 2013-10-08 | |||
| US8685394B2 | 2014-04-01 |
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OKUMURA YOSHIYUKI ET AL: "Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 27, no. 5, 25 January 2017 (2017-01-25), pages 1186 - 1192, XP029927656, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2017.01.067
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KONYA ET AL., PHARMACOLOGY & THERAPEUTICS, vol. 138, 2013, pages 485 - 502
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CHEN ET AL., NATURE MEDICINE, vol. 21, no. 4, 2015, pages 327 - 334
EL-SERAG, NEW ENGLAND J. MED., vol. 365, 2011, pages 1118 - 1127
OHTANI ET AL., CANCER RESEARCH, vol. 74, 2014, pages 1885 - 1889
FUERTES ET AL., J. EXP. MED., vol. 208, 2011, pages 2005 - 2016
SALMON ET AL., IMMUNITY, vol. 44, 2016, pages 924 - 938
ZELENAY ET AL., CELL, vol. 162, 2015, pages 1257 - 1270
STAHL; WERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
HALEBLIAN, J. PHARM. SCI., vol. 64, no. 8, August 1975 (1975-08-01), pages 1269 - 1288
T. HIGUCHI AND W. STELLA: "Pro-drugs as Novel Delivery Systems", vol. 14, ACS SYMPOSIUM SERIES
E. B. ROCHE,: "Bioreversible Carriers in Drug Design", 1987, PERGAMON PRESS
H BUNDGAARD: "Design of Prodrugs", 1985, ELSEVIER
E L ELIEL: "Stereochemistry of Organic Compounds", 1994, WILEY
GENNARO,: "Remington's Pharmaceutical Sciences, 18th ed.,", 1990, MACK PUBLISHING CO.
YOSHIMOTO ET AL., NATURE, vol. 499, 2013, pages 97 - 101
OKUMURA YOSHIYUKI ET AL: "Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 27, no. 5, 25 January 2017 (2017-01-25), pages 1186 - 1192, XP029927656, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2017.01.067
TORRES ET AL., SEMIN LIVER DIS., vol. 32, no. 1, 2012, pages 30 - 38
BHASKARAN ET AL., LANCET, vol. 384, 2014, pages 755 - 765
CALLE; KAAKS, NATURE REVIEWS CANCER, vol. 4, 2004, pages 579 - 591
CALLE ET AL., NEW ENGLAND J. MED., vol. 348, no. 17, 2003, pages 1625 - 1638
EL-SERAG; NEW ENGLAND, J. MED., vol. 365, 2011, pages 1118 - 1127
MARENGO ET AL., ANNUAL REVIEW OF MEDICINE, vol. 67, 2016, pages 103 - 117
MICHELOTTI ET AL., NAT. REV. GASTROENTEROL. HEPATOL., vol. 10, 2013, pages 656 - 665
STREBA ET AL., WORLD J. GASTROENTEROLOGY, vol. 21, no. 14, 2015, pages 4103 - 4110
KONYA ET AL., PHARMACOLOGY & THERAPEUTICS, vol. 138, 2013, pages 485 - 502
YOKOYAMA ET AL., PHARMACOL. REV., vol. 65, 2013, pages 1010 - 1052
MA ET AL., ONCOIMMUNOLOGY, vol. 2, no. 1, 2013, pages e22647
XIA ET AL., ONCOLOGY REPORTS, vol. 32, 2014, pages 1521 - 1530
XU ET AL., ONCOTARGET, vol. 7, no. 8, 2016, pages 8866 - 8878
CHEN ET AL., NATURE MEDICINE, vol. 21, no. 4, 2015, pages 327 - 334
EL-SERAG, NEW ENGLAND J. MED., vol. 365, 2011, pages 1118 - 1127
OHTANI ET AL., CANCER RESEARCH, vol. 74, 2014, pages 1885 - 1889
FUERTES ET AL., J. EXP. MED., vol. 208, 2011, pages 2005 - 2016
SALMON ET AL., IMMUNITY, vol. 44, 2016, pages 924 - 938
ZELENAY ET AL., CELL, vol. 162, 2015, pages 1257 - 1270
STAHL; WERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
HALEBLIAN, J. PHARM. SCI., vol. 64, no. 8, August 1975 (1975-08-01), pages 1269 - 1288
T. HIGUCHI AND W. STELLA: "Pro-drugs as Novel Delivery Systems", vol. 14, ACS SYMPOSIUM SERIES
E. B. ROCHE,: "Bioreversible Carriers in Drug Design", 1987, PERGAMON PRESS
H BUNDGAARD: "Design of Prodrugs", 1985, ELSEVIER
E L ELIEL: "Stereochemistry of Organic Compounds", 1994, WILEY
GENNARO,: "Remington's Pharmaceutical Sciences, 18th ed.,", 1990, MACK PUBLISHING CO.
YOSHIMOTO ET AL., NATURE, vol. 499, 2013, pages 97 - 101
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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