Title:
USE OF EPHB4 AS TARGET IN SCREENING OF DRUGS OR MODELS FOR INCREASING INSULIN SENSITIVITY
Document Type and Number:
WIPO Patent Application WO/2021/184918
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of protein and genetic engineering, and specifically discloses use of an erythropoietin human hepatocyte receptor B4 as a target in screening and preparing a biological formulation or medicament for increasing sensitivity to insulin. Also disclosed is use of an erythropoietin human hepatocyte receptor B4 in preparing an insulin-sensitized mouse model. On the basis of insulin signal regulation, a protein EphB4 capable of interacting with an insulin receptor (InsR) is found. The protein can interact with InsR, and insulin stimulation can promote the interaction between the two, which provides a basis for insulin resistance in the case of hyperinsulinaemia. Over-expression of EphB4 can promote degradation of InsR. Inhibition of EphB4 can enhance the sensitivity to insulin and improve insulin resistance.
Inventors:
LI PINGPING (CN)
LIU XINGFENG (CN)
CUI BING (CN)
WANG KAI (CN)
CHEN JINGWEN (CN)
HOU SHAOCONG (CN)
KONG LIJUAN (CN)
JIANG QIAN (CN)
MA CHUNXIAO (CN)
LIU XINGFENG (CN)
CUI BING (CN)
WANG KAI (CN)
CHEN JINGWEN (CN)
HOU SHAOCONG (CN)
KONG LIJUAN (CN)
JIANG QIAN (CN)
MA CHUNXIAO (CN)
Application Number:
PCT/CN2020/141441
Publication Date:
September 23, 2021
Filing Date:
December 30, 2020
Export Citation:
Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
A61K45/00; A61P3/10
Domestic Patent References:
| WO2009015908A2 | 2009-02-05 | |||
| WO2009006336A1 | 2009-01-08 | |||
| WO2007130697A2 | 2007-11-15 |
Foreign References:
| CN108785310A | 2018-11-13 | |||
| CN103238565A | 2013-08-14 |
Other References:
HUANG GENA, LI MAN: "The role of EphB4 and IGF-IR expression in breast cancer cells", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, E-CENTURY PUBLISHING CORPORATION, US, vol. 8, no. 5, 15 May 2015 (2015-05-15), US, pages 5997 - 6004, XP055852359, ISSN: 1936-2625
LEE KATE L.; AITKEN JACQUELINE F.; HSU HUAI-L.; WILLIAMS GEOFFREY M.; BRIMBLE MARGARET A.; COOPER GARTH J.S.: "Glucoregulatory activity of vesiculin in insulin sensitive and resistant mice", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 116, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 1 - 7, XP085693666, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2019.04.011
See also references of EP 4140503A4
LEE KATE L.; AITKEN JACQUELINE F.; HSU HUAI-L.; WILLIAMS GEOFFREY M.; BRIMBLE MARGARET A.; COOPER GARTH J.S.: "Glucoregulatory activity of vesiculin in insulin sensitive and resistant mice", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 116, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 1 - 7, XP085693666, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2019.04.011
See also references of EP 4140503A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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