Title:
USE OF FA-TYPE LIPID COMPOUNDS IN PREPARATION OF NUCLEIC ACID DELIVERY REAGENT AND RELATED PRODUCT
Document Type and Number:
WIPO Patent Application WO/2023/005971
Kind Code:
A1
Abstract:
A use of one or more lipid compounds in the delivery of nucleic acids, and a lipid nucleic acid mixture, pharmaceutical composition or kit comprising the lipid compounds and nucleic acids. The lipid compounds provided above can promote the absorption, particularly oral absorption, of nucleic acids, and promote the entry of nucleic acids into target sites in a subject in need thereof.
Inventors:
JIANG CHENGYU (CN)
MA YIMING (CN)
XU LONGXIN (CN)
MA YIMING (CN)
XU LONGXIN (CN)
Application Number:
PCT/CN2022/108245
Publication Date:
February 02, 2023
Filing Date:
July 27, 2022
Export Citation:
Assignee:
INST BASIC MEDICAL SCIENCES CAMS (CN)
International Classes:
C07C219/00; A61K48/00; C07C229/00
Domestic Patent References:
| WO2011075656A1 | 2011-06-23 | |||
| WO2011141705A1 | 2011-11-17 | |||
| WO2009088891A1 | 2009-07-16 | |||
| WO2019184663A1 | 2019-10-03 | |||
| WO2018177383A1 | 2018-10-04 | |||
| WO2019184991A1 | 2019-10-03 |
Foreign References:
| US20200368173A1 | 2020-11-26 |
Other References:
"Handbook of Chemistry and Physics", 1999, UNIVERSITY SCIENCE BOOKS
"March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
BATZER ET AL., NUCLEIC ACID RES., vol. 19, 1991, pages 5081
OHTSUKA ET AL., J. BIOL. CHEM., vol. 260, 1985, pages 2605 - 2608
ROSSOLINI ET AL., MOL. CELL. PROBES, vol. 8, 1994, pages 91 - 98
BLIGH E.G.DYER, W. J.: "A rapid method for total lipid extraction and purification", CAN. J. BIOCHEM. PHYSIOL., vol. 37, 1959, pages 911 - 917, XP000998224
"Real-time quantification of microRNAs by stem-loop RT-PCR", NUCLEIC ACIDS RES., vol. 33, no. 20, 27 November 2005 (2005-11-27), pages el79
"March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
BATZER ET AL., NUCLEIC ACID RES., vol. 19, 1991, pages 5081
OHTSUKA ET AL., J. BIOL. CHEM., vol. 260, 1985, pages 2605 - 2608
ROSSOLINI ET AL., MOL. CELL. PROBES, vol. 8, 1994, pages 91 - 98
BLIGH E.G.DYER, W. J.: "A rapid method for total lipid extraction and purification", CAN. J. BIOCHEM. PHYSIOL., vol. 37, 1959, pages 911 - 917, XP000998224
"Real-time quantification of microRNAs by stem-loop RT-PCR", NUCLEIC ACIDS RES., vol. 33, no. 20, 27 November 2005 (2005-11-27), pages el79
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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