Title:
USE OF FULLERENE STRUCTURE IN PREPARATION OF MEDICAMENT FOR TREATING TUMOR
Document Type and Number:
WIPO Patent Application WO/2018/064963
Kind Code:
A1
Abstract:
Provided is use of a fullerene structure comprising at least one active ingredient selected from a group consisting of an oil-soluble hollow fullerene, an oil-soluble metallofullerene, a composition of the oil-soluble hollow fullerene and the oil-soluble metallofullerene, a water-soluble hollow fullerenes, a water-soluble metallofullerene, a combination of the water-soluble hollow fullerene and the water-soluble metallofullerene, a pharmaceutically acceptable ester of the above six, or a pharmaceutically acceptable salt of the above six, in preparation of a medicament for treating tumor. Provided is also a pharmaceutical composition, a health care product or a health food comprising the fullerene structure. Further provided is a preparation method of the fullerene structure.
Inventors:
WANG CHUNRU (CN)
ZHEN MINGMING (CN)
ZHOU YUE (CN)
BAI CHUNLI (CN)
ZHEN MINGMING (CN)
ZHOU YUE (CN)
BAI CHUNLI (CN)
Application Number:
PCT/CN2017/104665
Publication Date:
April 12, 2018
Filing Date:
September 29, 2017
Export Citation:
Assignee:
BEIJING FULLCAN BIOTECHNOLOGY CO LTD (CN)
INST OF CHEMISTRY OF CHINESE ACADEMY OF SCIENCES (CN)
INST OF CHEMISTRY OF CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K33/44; A61K33/00; A61K33/24; A61K33/244; A61K41/00; A61P35/00
Foreign References:
| CN106620727A | 2017-05-10 | |||
| CN106619715A | 2017-05-10 | |||
| CN107137423A | 2017-09-08 | |||
| CN104127872A | 2014-11-05 | |||
| CN104127873A | 2014-11-05 | |||
| CN104997646A | 2015-10-28 | |||
| CN102674312A | 2012-09-19 |
Other References:
JIAO, FANG ET AL.: "Trends in Studies on Chemical Modification and Biomedical Applications of Fullerenes", ASIAN JOURNAL OF ECOTOXICOLOGY, vol. 5, no. 4, 31 August 2010 (2010-08-31), pages 470, ISSN: 1673-5897
SHU, C.Y. ET AL.: "Synthesis and Characterization of a New Water-soluble Endohedral Metallofullerene for MRI Contrast Agents", CARBON, vol. 44, no. 3, 3 October 2005 (2005-10-03), pages 496 - 500, XP005172470, ISSN: 0008-6223
JIANG, GUICHANG ET AL.: "Study on Synthesis and in Vitro Antitumour Activity of Fullerence-Lysine Derivative", MATERIALS REVIEW, vol. 19, no. 8, 31 August 2005 (2005-08-31), ISSN: 1005-023X
ZHENG, J.P . ET AL.: "Multifunctional Gadofulleride Nanoprobe for Magnetic Resonance Imaging/Fluorescent Dual Modality Molecular Imaging and Free Radical Scavenging", CARBON, vol. 65, 16 August 2013 (2013-08-16), pages 175 - 180, XP028726074, ISSN: 0008-6223
SHU, C.Y. ET AL.: "Synthesis and Characterization of a New Water-soluble Endohedral Metallofullerene for MRI Contrast Agents", CARBON, vol. 44, no. 3, 3 October 2005 (2005-10-03), pages 496 - 500, XP005172470, ISSN: 0008-6223
JIANG, GUICHANG ET AL.: "Study on Synthesis and in Vitro Antitumour Activity of Fullerence-Lysine Derivative", MATERIALS REVIEW, vol. 19, no. 8, 31 August 2005 (2005-08-31), ISSN: 1005-023X
ZHENG, J.P . ET AL.: "Multifunctional Gadofulleride Nanoprobe for Magnetic Resonance Imaging/Fluorescent Dual Modality Molecular Imaging and Free Radical Scavenging", CARBON, vol. 65, 16 August 2013 (2013-08-16), pages 175 - 180, XP028726074, ISSN: 0008-6223
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