Title:
USE OF GLUCOSYLCERAMIDE SYNTHASE GENE-DEFICIENT T CELL AND THERAPEUTIC UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/085414
Kind Code:
A1
Abstract:
The present invention provides: an activated T cell in which the expression of an immune checkpoint molecule is suppressed; a method for preparing the T cell; and a method for screening a substance which is usable in preparing the T cell. More specifically, a means for solving the problem of the present invention comprises: a method for producing or inducing a T cell in which the expression of an immune checkpoint molecule is not induced, said method comprising reducing or losing the function of glucosylceramide synthase (UGCG) or a ganglioside of a T cell; and a T cell having been produced or induced by this method.
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Inventors:
YAMASHITA TADASHI (JP)
NAGANE MASAKI (JP)
IKEDA TERUO (JP)
MIYATAKE SHOICHIRO (JP)
OKAMOTO MARIKO (JP)
NAGANE MASAKI (JP)
IKEDA TERUO (JP)
MIYATAKE SHOICHIRO (JP)
OKAMOTO MARIKO (JP)
Application Number:
PCT/JP2019/041627
Publication Date:
April 30, 2020
Filing Date:
October 24, 2019
Export Citation:
Assignee:
SCHOOL CORPORATION AZABU VETERINARY MEDICINE EDUCATIONAL INST (JP)
TELLA INC (JP)
TELLA INC (JP)
International Classes:
C12N15/54; A61K35/17; A61K45/00; A61P35/00; A61P43/00; C12N5/0783; C12N5/10; C12Q1/48; G01N33/15; G01N33/50; C12N9/10
Domestic Patent References:
| WO2010050584A1 | 2010-05-06 | |||
| WO2018099539A1 | 2018-06-07 | |||
| WO2005049827A2 | 2005-06-02 |
Other References:
FELDING-HABERMANN, B. ET AL.: "A Ceramide Analogue Inhibits T Cell Proliferative Response through Inhibition of Glycosphingolipid Synthesis and Enhancement of N, N-Dimethylsphingosine Synthesis", BIOCHEMISTRY, vol. 29, no. 26, 1990, pages 6314 - 6322, XP008148913, DOI: 10.1021/bi00478a028
SIMPSON, M.A. ET AL.: "Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of- function mutation of GM3 synthase", NATURE GENETICS, vol. 36, no. 11, November 2004 (2004-11-01), pages 1225 - 1229, XP008148902, DOI: 10.1038/ng1460
PARDOLL, NAT REV CANCER, vol. 12, 2012, pages 252 - 264
NAGAFUKU ET AL., PROC NATL ACAD SCI USA., vol. 109, no. 6, pages E336 - 42
YAMASHITA ET AL., GENESIS, vol. 43, 2005, pages 175 - 180
SIMPSON, M.A. ET AL.: "Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of- function mutation of GM3 synthase", NATURE GENETICS, vol. 36, no. 11, November 2004 (2004-11-01), pages 1225 - 1229, XP008148902, DOI: 10.1038/ng1460
PARDOLL, NAT REV CANCER, vol. 12, 2012, pages 252 - 264
NAGAFUKU ET AL., PROC NATL ACAD SCI USA., vol. 109, no. 6, pages E336 - 42
YAMASHITA ET AL., GENESIS, vol. 43, 2005, pages 175 - 180
Attorney, Agent or Firm:
OKUHARA Koji et al. (JP)
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