Title:
USE OF HCN INHIBITORS FOR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2018/196782
Kind Code:
A1
Abstract:
Described are methods for treating cancers overexpressing hyperpolarization activated cyclic nucleotide-gated channel (HCN) isoforms HCN1, HCN2, HCN3, and/or HCN4. The cancers are treated by administering to a subject in need of treatment an effective amount of an HCN inhibitor. The HCN inhibitor can be an inhibitor of HCN1, HCN2, HCN3, or HCN4, or an inhibitor that inhibits any combination of HCN1, HCN2, HCN3, and HCN4. The described methods are useful for reducing tumor size, putting cancer in remission, and reducing or stopping proliferation of cancer stem cells.
Inventors:
KHOO UI SOON (CN)
TSOI HO FRANKIE (CN)
GONG CHUN JADE (CN)
LEE KIN WAH TERENCE (CN)
TSOI HO FRANKIE (CN)
GONG CHUN JADE (CN)
LEE KIN WAH TERENCE (CN)
Application Number:
PCT/CN2018/084417
Publication Date:
November 01, 2018
Filing Date:
April 25, 2018
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
A61K38/00; A61P35/00; C12N15/00
Domestic Patent References:
| WO2010140694A1 | 2010-12-09 | |||
| WO2004065580A2 | 2004-08-05 | |||
| WO1991009967A1 | 1991-07-11 | |||
| WO1993017105A1 | 1993-09-02 | |||
| WO1998046645A2 | 1998-10-22 | |||
| WO1998050433A2 | 1998-11-12 | |||
| WO1998024893A2 | 1998-06-11 | |||
| WO1998016654A1 | 1998-04-23 | |||
| WO1996034096A1 | 1996-10-31 | |||
| WO1996033735A1 | 1996-10-31 | |||
| WO1991010741A1 | 1991-07-25 | |||
| WO2000050900A2 | 2000-08-31 | |||
| WO1996040039A2 | 1996-12-19 |
Foreign References:
| US20090069296A1 | 2009-03-12 | |||
| US6311415B1 | 2001-11-06 | |||
| US5807715A | 1998-09-15 | |||
| US4816567A | 1989-03-28 | |||
| US4816397A | 1989-03-28 | |||
| EP0239400A2 | 1987-09-30 | |||
| US5225539A | 1993-07-06 | |||
| US5530101A | 1996-06-25 | |||
| US5585089A | 1996-12-17 | |||
| EP0592106A1 | 1994-04-13 | |||
| EP0519596A1 | 1992-12-23 | |||
| US5565332A | 1996-10-15 | |||
| US5766886A | 1998-06-16 | |||
| US6407213B1 | 2002-06-18 | |||
| US4444887A | 1984-04-24 | |||
| US4716111A | 1987-12-29 | |||
| US5916771A | 1999-06-29 | |||
| US5413923A | 1995-05-09 | |||
| US5625126A | 1997-04-29 | |||
| US5633425A | 1997-05-27 | |||
| US5569825A | 1996-10-29 | |||
| US5661016A | 1997-08-26 | |||
| US5545806A | 1996-08-13 | |||
| US5814318A | 1998-09-29 | |||
| US5939598A | 1999-08-17 | |||
| US20050037000A1 | 2005-02-17 | |||
| US20050064514A1 | 2005-03-24 | |||
| US20040049014A1 | 2004-03-11 | |||
| US20030229208A1 | 2003-12-11 | |||
| US6350861B1 | 2002-02-26 | |||
| US6180370B1 | 2001-01-30 | |||
| US5693762A | 1997-12-02 | |||
| US5693761A | 1997-12-02 | |||
| US3610795A | 1971-10-05 | |||
| US6699475B1 | 2004-03-02 | |||
| GB2241703A | 1991-09-11 | |||
| US5683886A | 1997-11-04 | |||
| US5571711A | 1996-11-05 | |||
| US6677157B1 | 2004-01-13 | |||
| US6673545B2 | 2004-01-06 | |||
| US7176197B2 | 2007-02-13 | |||
| US6331415B1 | 2001-12-18 | |||
| GB2188638A | 1987-10-07 | |||
| GB2209757A | 1989-05-24 | |||
| US5721367A | 1998-02-24 | |||
| US5837243A | 1998-11-17 | |||
| US6130364A | 2000-10-10 |
Other References:
YEO ET AL., BMJ-BRITISH MEDICAL JOURNAL, vol. 348, 2014
COLLIGNON ET AL., BREAST CANCER-TARGETS AND THERAPY, vol. 8, 2016, pages 93 - 107
ZEICHNER ET AL., BREAST CANCER-BASIC AND CLINICAL RESEARCH, vol. 10, 2016, pages 25 - 36
MORRISON, SCIENCE, vol. 229, 1985, pages 1202
OI, BIOTECHNIQUES, vol. 4, 1986, pages 214
GILLIES ET AL., J. IMMUNOL. METHODS, vol. 125, 1989, pages 191 - 202
PADLAN, MOLECULAR IMMUNOLOGY, vol. 28, no. 4/5, 1991, pages 489 - 498
STUDNICKA ET AL., PROTEIN ENGINEERING, vol. 7, no. 6, 1994, pages 805 - 814
ROGUSKA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 969
ROGUSKA ET AL., PNAS, vol. 91, 1994, pages 969 - 973
TAN ET AL., J. IMMUNOL., vol. 169, 2002, pages 1119 - 1125
CALDAS ET AL., PROTEIN ENG, vol. 13, 2000, pages 353 - 360
MOREA ET AL., METHODS, vol. 20, 2000, pages 267 - 79
BACA ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 10678 - 10684
ROGUSKA ET AL., PROTEIN ENG, vol. 9, 1996, pages 895 - 904
COUTO ET AL., CANCER RES., vol. 55, no. 23 Supp, 1995, pages 5973s - 5977s
SANDHU, GENE, vol. 150, 1994, pages 409 - 10
PEDERSEN ET AL., J. MOL. BIOL., vol. 235, 1994, pages 959 - 973
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CHOTHIA ET AL.: "Structural Determinants In The Sequences Of Immunoglobulin Variable Domain", J. MOL. BIOL., vol. 278, 1998, pages 457 - 479, XP004453679, DOI: 10.1006/jmbi.1998.1653
POOLOS NP. ET AL.: "Jasper's Basic Mechanisms of the Epilepsies [Internet]", 2012, NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, article "Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy"
SANTORO ET AL., JNEUROSCI., vol. 20, 2000, pages 5264 - 5275
THOLLON ET AL., BRITISH JOURNAL OF PHARMACOLOGY, vol. 150, 2007, pages 37 - 46
POSTEA, NATURE REVIEWS DRUG DISCOVERY, vol. 10, 2011, pages 903 - 914
KABAT E. A. ET AL.: "Sequences of Proteins of Immunological Interest", NATIONAL INSTITUTES OF HEALTH, 1987
VAN DEN BRUGGEN ET AL., SCIENCE, vol. 254, 1991, pages 1292 - 1293
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
HOLLINGERHUDSON, NATURE BIOTECH, vol. 23, no. 9, 2005, pages 1126 - 1136
HOLLIGERWINTER, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
PEI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 9637 - 9642
ILIADES ET AL., FEBS LETT, vol. 409, 1997, pages 437 - 441
DE GENST ET AL., J. BIOL. CHEM., vol. 280, 2005, pages 14114 - 14121
DE GENST ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 53593 - 53601
DOOLEYFLAJNIK, EUR. J. IMMUNOL., vol. 35, 2005, pages 936 - 945
STRELTSOVNUTTALL, IMMUNOL. LETT., vol. 97, 2005, pages 159 - 160
STRELTSOV ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 12444 - 12449
CORTEZ-RETAMOZO ET AL., CANCER RES., vol. 64, 2004, pages 6200 - 6206
DOTTORINI ET AL., BIOCHEMISTRY, vol. 43, 2004, pages 622 - 628
JESPERS ET AL., J. MOL. BIOL., vol. 337, 2004, pages 893 - 903
LINSLEY, NAT. IMMUNOL, vol. 6, 2005, pages 231 - 232
CASEY ET AL., BR. J. CANCER, vol. 86, 2002, pages 1401 - 1410
WEIR ET AL., BIOCHEM. SOC. TRANS., vol. 30, 2002, pages 512 - 516
DOLEZAL ET AL., PROTEIN ENG., vol. 16, 2003, pages 47 - 56
POWER ET AL., METHODS MOL. BIOL., vol. 207, 2003, pages 335 - 350
ARNDT ET AL., FEBS LETT., vol. 578, 2004, pages 257 - 261
GRIFFITHS ET AL., J. NUCL. MED., vol. 45, 2004, pages 30 - 39
LE GALL ET AL., PROTEIN ENG. DES. SEL., vol. 17, 2004, pages 357 - 366
WITTEL ET AL., NUCL. MED. BIOL., vol. 32, 2005, pages 157 - 164
KENANOVA ET AL., CANCER RES., vol. 65, 2005, pages 5907 - 5916
GROSSE-HOVEST ET AL., INT. J. CANCER, 7 July 2005 (2005-07-07)
HOLLIGER ET AL., CANCER RES, vol. 59, 1999, pages 2909 - 2916
PATTERSEN ET AL., J. COMPUT. CHEM., vol. 25, 2004, pages 1605 - 1612
SHEN ET AL., J. NUCL. MED., vol. 46, 2005, pages 642 - 651
NELLIS ET AL., BIOTECHNOL. PROG., vol. 21, 2005, pages 221 - 232
EBBINGHAUS ET AL., INT. J. CANCER, vol. 116, 2005, pages 304 - 313
WONG ET AL., CLIN. CANCER RES., vol. 10, 2004, pages 5014 - 5021
HULSTEIN ET AL., BLOOD, 12 July 2005 (2005-07-12), Retrieved from the Internet
VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 1536
LONBERGHUSZAR, INT. REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
ROGUSKA ET AL., PROC. NATL. ACAD. SCI., vol. 91, 1994, pages 969 - 973
CALDAS ET AL., PROTEIN ENG., vol. 13, 2000, pages 353 - 60
ROGUSKA ET AL., PROTEIN ENG., vol. 9, 1996, pages 895 - 904
PRESTA, CURRO OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
FIRE, A. ET AL., NATURE, vol. 391, 1998, pages 806 - 11
NAPOLI, C. ET AL., PLANT CELL, vol. 2, 1990, pages 279 - 89
HANNON, G.J., NATURE, vol. 418, 2002, pages 244 - 51
ELBASHIR, S.M. ET AL., GENES DEV., vol. 15, 2001, pages 188 - 200
ELBASHIR, S.M. ET AL., NATURE, vol. 411, 2001, pages 494 - 498
HAMMOND, S.M. ET AL., NATURE, vol. 404, 2000, pages 293 - 6
NYKANEN, A. ET AL., CELL, vol. 107, 2001, pages 309 - 21
MARTINEZ, J. ET AL., CELL, vol. 110, 2002, pages 563 - 74
UI-TEI, K. ET AL., FEBS LETT, vol. 479, 2000, pages 79 - 82
SAMBROOK ET AL.: "A Laboratory Manual, Third Edition", 2001, article "Molecular Cloning"
JAGER ET AL., INT. J. CANCER, vol. 106, 2003, pages 817 - 20
KENNEDY ET AL., INT. REV. IMMUNOL., vol. 22, 2003, pages 141 - 72
SCANLAN ET AL., CANCER LF IIIN., vol. 4, no. 1, 2004
BAST ET AL., N. ENG. J. MED., vol. 309, 1983, pages 883
LLOYD ET AL., INT. J. CANC., vol. 71, 1997, pages 842
SARANDAKOU ET AL., ACTA ONCOL., vol. 36, 1997, pages 755
SARANDAKOU ET AL., EUR. J. GYNAECOL. ONCOL., vol. 19, 1998, pages 73
GEBAUER ET AL., ANTICANCER RES., vol. 17, no. 4B, 1997, pages 2939
KUDOH ET AL., GYNECOL. OBSTET. INVEST., vol. 47, 1999, pages 52
HIROKAWA ET AL., SURG. TODAY, vol. 28, 1998, pages 349
ALFTHAN ET AL., CANCER RES., vol. 52, 1992, pages 4628 - 33
CHANG ET AL., INT. J. CANCER, vol. 51, 1992, pages 548
CHANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 136
CHOWDHURY ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 669
"GenBank", Database accession no. AF055473
YOSHINO ET AL., J. IMMUNOL., vol. 152, 1994, pages 2393
DISIS ET AL., CANE. RES., vol. 54, no. 16, 1994
JAKOBOVITS ET AL., NATURE, vol. 362, 1993, pages 255 - 258
TROWBRIDGEOMARY, PROC. NAT. ACAD. USA, vol. 78, 1981, pages 3039
BARNES ET AL., PROC. NAT. ACAD. SCI. USA, vol. 86, 1989, pages 7159
"G enBank", Database accession no. U87459
TOPALIAN ET AL., PROC. NAT. ACAD. SCI. USA, vol. 91, 1994, pages 9461
WEBER ET AL., J. CLIN. INVEST, vol. 102, 1998, pages 1258
ADEMA ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 20126
GOLDFREEDMAN, J. EXP. MED., vol. 121, 1985, pages 439
BROWN ET AL., J. IMMUNOL., vol. 127, 1981, pages 539 - 46
ROSE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 83, 1986, pages 1261 - 61
MCMANUS ET AL., CANCER RES., vol. 36, 1976, pages 3476 - 81
YOSHIMURA ET AL., CANCER, vol. 73, 1994, pages 2745 - 52
YAMAGUCHI ET AL., BR. J. CANCER, vol. 60, 1989, pages 382 - 84
HOON ET AL., INT. J. CANCER, vol. 43, 1989, pages 857 - 62
ANDO ET AL., INT. J. CANCER, vol. 40, 1987, pages 12 - 17
TSUCHIDA ET AL., J. NATL. CANCER, vol. 78, 1987, pages 55 - 60
LEHMANN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 9891 - 95
LEHMANN ET AL., CANCER RES., vol. 47, 1987, pages 841 - 45
VIJAYASARDAHI ET AL., J. EXP. MED., vol. 171, 1990, pages 1375 - 80
NATALI ET AL., CANCER, vol. 59, 1987, pages 55 - 63
DATTA ET AL., J. CLIN. ONCOL., vol. 12, 1994, pages 475 - 82
SCANLAN ET AL., CANCER IMMUN., vol. 4, no. 1, 2004
BOERNER ET AL., J. IMMUNOL., vol. 147, no. 1, 1991, pages 86 - 95
LEWIS, GENETIC ENGINEERING NEWS, vol. 12, no. 1, 1992
JAKOBOVITS ET AL., PNAS, vol. 90, 1993, pages 2551 - 255
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
GUATELLI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 1874 - 1878
"Short Protocols in Molecular Biology", 1992, GREEN PUBLISHING ASSOCIATES AND JOHN WILEY & SONS
See also references of EP 3615052A4
COLLIGNON ET AL., BREAST CANCER-TARGETS AND THERAPY, vol. 8, 2016, pages 93 - 107
ZEICHNER ET AL., BREAST CANCER-BASIC AND CLINICAL RESEARCH, vol. 10, 2016, pages 25 - 36
MORRISON, SCIENCE, vol. 229, 1985, pages 1202
OI, BIOTECHNIQUES, vol. 4, 1986, pages 214
GILLIES ET AL., J. IMMUNOL. METHODS, vol. 125, 1989, pages 191 - 202
PADLAN, MOLECULAR IMMUNOLOGY, vol. 28, no. 4/5, 1991, pages 489 - 498
STUDNICKA ET AL., PROTEIN ENGINEERING, vol. 7, no. 6, 1994, pages 805 - 814
ROGUSKA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 969
ROGUSKA ET AL., PNAS, vol. 91, 1994, pages 969 - 973
TAN ET AL., J. IMMUNOL., vol. 169, 2002, pages 1119 - 1125
CALDAS ET AL., PROTEIN ENG, vol. 13, 2000, pages 353 - 360
MOREA ET AL., METHODS, vol. 20, 2000, pages 267 - 79
BACA ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 10678 - 10684
ROGUSKA ET AL., PROTEIN ENG, vol. 9, 1996, pages 895 - 904
COUTO ET AL., CANCER RES., vol. 55, no. 23 Supp, 1995, pages 5973s - 5977s
SANDHU, GENE, vol. 150, 1994, pages 409 - 10
PEDERSEN ET AL., J. MOL. BIOL., vol. 235, 1994, pages 959 - 973
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CHOTHIA ET AL.: "Structural Determinants In The Sequences Of Immunoglobulin Variable Domain", J. MOL. BIOL., vol. 278, 1998, pages 457 - 479, XP004453679, DOI: 10.1006/jmbi.1998.1653
POOLOS NP. ET AL.: "Jasper's Basic Mechanisms of the Epilepsies [Internet]", 2012, NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, article "Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy"
SANTORO ET AL., JNEUROSCI., vol. 20, 2000, pages 5264 - 5275
THOLLON ET AL., BRITISH JOURNAL OF PHARMACOLOGY, vol. 150, 2007, pages 37 - 46
POSTEA, NATURE REVIEWS DRUG DISCOVERY, vol. 10, 2011, pages 903 - 914
KABAT E. A. ET AL.: "Sequences of Proteins of Immunological Interest", NATIONAL INSTITUTES OF HEALTH, 1987
VAN DEN BRUGGEN ET AL., SCIENCE, vol. 254, 1991, pages 1292 - 1293
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
HOLLINGERHUDSON, NATURE BIOTECH, vol. 23, no. 9, 2005, pages 1126 - 1136
HOLLIGERWINTER, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
PEI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 9637 - 9642
ILIADES ET AL., FEBS LETT, vol. 409, 1997, pages 437 - 441
DE GENST ET AL., J. BIOL. CHEM., vol. 280, 2005, pages 14114 - 14121
DE GENST ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 53593 - 53601
DOOLEYFLAJNIK, EUR. J. IMMUNOL., vol. 35, 2005, pages 936 - 945
STRELTSOVNUTTALL, IMMUNOL. LETT., vol. 97, 2005, pages 159 - 160
STRELTSOV ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 12444 - 12449
CORTEZ-RETAMOZO ET AL., CANCER RES., vol. 64, 2004, pages 6200 - 6206
DOTTORINI ET AL., BIOCHEMISTRY, vol. 43, 2004, pages 622 - 628
JESPERS ET AL., J. MOL. BIOL., vol. 337, 2004, pages 893 - 903
LINSLEY, NAT. IMMUNOL, vol. 6, 2005, pages 231 - 232
CASEY ET AL., BR. J. CANCER, vol. 86, 2002, pages 1401 - 1410
WEIR ET AL., BIOCHEM. SOC. TRANS., vol. 30, 2002, pages 512 - 516
DOLEZAL ET AL., PROTEIN ENG., vol. 16, 2003, pages 47 - 56
POWER ET AL., METHODS MOL. BIOL., vol. 207, 2003, pages 335 - 350
ARNDT ET AL., FEBS LETT., vol. 578, 2004, pages 257 - 261
GRIFFITHS ET AL., J. NUCL. MED., vol. 45, 2004, pages 30 - 39
LE GALL ET AL., PROTEIN ENG. DES. SEL., vol. 17, 2004, pages 357 - 366
WITTEL ET AL., NUCL. MED. BIOL., vol. 32, 2005, pages 157 - 164
KENANOVA ET AL., CANCER RES., vol. 65, 2005, pages 5907 - 5916
GROSSE-HOVEST ET AL., INT. J. CANCER, 7 July 2005 (2005-07-07)
HOLLIGER ET AL., CANCER RES, vol. 59, 1999, pages 2909 - 2916
PATTERSEN ET AL., J. COMPUT. CHEM., vol. 25, 2004, pages 1605 - 1612
SHEN ET AL., J. NUCL. MED., vol. 46, 2005, pages 642 - 651
NELLIS ET AL., BIOTECHNOL. PROG., vol. 21, 2005, pages 221 - 232
EBBINGHAUS ET AL., INT. J. CANCER, vol. 116, 2005, pages 304 - 313
WONG ET AL., CLIN. CANCER RES., vol. 10, 2004, pages 5014 - 5021
HULSTEIN ET AL., BLOOD, 12 July 2005 (2005-07-12), Retrieved from the Internet
VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 1536
LONBERGHUSZAR, INT. REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
ROGUSKA ET AL., PROC. NATL. ACAD. SCI., vol. 91, 1994, pages 969 - 973
CALDAS ET AL., PROTEIN ENG., vol. 13, 2000, pages 353 - 60
ROGUSKA ET AL., PROTEIN ENG., vol. 9, 1996, pages 895 - 904
PRESTA, CURRO OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
FIRE, A. ET AL., NATURE, vol. 391, 1998, pages 806 - 11
NAPOLI, C. ET AL., PLANT CELL, vol. 2, 1990, pages 279 - 89
HANNON, G.J., NATURE, vol. 418, 2002, pages 244 - 51
ELBASHIR, S.M. ET AL., GENES DEV., vol. 15, 2001, pages 188 - 200
ELBASHIR, S.M. ET AL., NATURE, vol. 411, 2001, pages 494 - 498
HAMMOND, S.M. ET AL., NATURE, vol. 404, 2000, pages 293 - 6
NYKANEN, A. ET AL., CELL, vol. 107, 2001, pages 309 - 21
MARTINEZ, J. ET AL., CELL, vol. 110, 2002, pages 563 - 74
UI-TEI, K. ET AL., FEBS LETT, vol. 479, 2000, pages 79 - 82
SAMBROOK ET AL.: "A Laboratory Manual, Third Edition", 2001, article "Molecular Cloning"
JAGER ET AL., INT. J. CANCER, vol. 106, 2003, pages 817 - 20
KENNEDY ET AL., INT. REV. IMMUNOL., vol. 22, 2003, pages 141 - 72
SCANLAN ET AL., CANCER LF IIIN., vol. 4, no. 1, 2004
BAST ET AL., N. ENG. J. MED., vol. 309, 1983, pages 883
LLOYD ET AL., INT. J. CANC., vol. 71, 1997, pages 842
SARANDAKOU ET AL., ACTA ONCOL., vol. 36, 1997, pages 755
SARANDAKOU ET AL., EUR. J. GYNAECOL. ONCOL., vol. 19, 1998, pages 73
GEBAUER ET AL., ANTICANCER RES., vol. 17, no. 4B, 1997, pages 2939
KUDOH ET AL., GYNECOL. OBSTET. INVEST., vol. 47, 1999, pages 52
HIROKAWA ET AL., SURG. TODAY, vol. 28, 1998, pages 349
ALFTHAN ET AL., CANCER RES., vol. 52, 1992, pages 4628 - 33
CHANG ET AL., INT. J. CANCER, vol. 51, 1992, pages 548
CHANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 136
CHOWDHURY ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 669
"GenBank", Database accession no. AF055473
YOSHINO ET AL., J. IMMUNOL., vol. 152, 1994, pages 2393
DISIS ET AL., CANE. RES., vol. 54, no. 16, 1994
JAKOBOVITS ET AL., NATURE, vol. 362, 1993, pages 255 - 258
TROWBRIDGEOMARY, PROC. NAT. ACAD. USA, vol. 78, 1981, pages 3039
BARNES ET AL., PROC. NAT. ACAD. SCI. USA, vol. 86, 1989, pages 7159
"G enBank", Database accession no. U87459
TOPALIAN ET AL., PROC. NAT. ACAD. SCI. USA, vol. 91, 1994, pages 9461
WEBER ET AL., J. CLIN. INVEST, vol. 102, 1998, pages 1258
ADEMA ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 20126
GOLDFREEDMAN, J. EXP. MED., vol. 121, 1985, pages 439
BROWN ET AL., J. IMMUNOL., vol. 127, 1981, pages 539 - 46
ROSE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 83, 1986, pages 1261 - 61
MCMANUS ET AL., CANCER RES., vol. 36, 1976, pages 3476 - 81
YOSHIMURA ET AL., CANCER, vol. 73, 1994, pages 2745 - 52
YAMAGUCHI ET AL., BR. J. CANCER, vol. 60, 1989, pages 382 - 84
HOON ET AL., INT. J. CANCER, vol. 43, 1989, pages 857 - 62
ANDO ET AL., INT. J. CANCER, vol. 40, 1987, pages 12 - 17
TSUCHIDA ET AL., J. NATL. CANCER, vol. 78, 1987, pages 55 - 60
LEHMANN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 9891 - 95
LEHMANN ET AL., CANCER RES., vol. 47, 1987, pages 841 - 45
VIJAYASARDAHI ET AL., J. EXP. MED., vol. 171, 1990, pages 1375 - 80
NATALI ET AL., CANCER, vol. 59, 1987, pages 55 - 63
DATTA ET AL., J. CLIN. ONCOL., vol. 12, 1994, pages 475 - 82
SCANLAN ET AL., CANCER IMMUN., vol. 4, no. 1, 2004
BOERNER ET AL., J. IMMUNOL., vol. 147, no. 1, 1991, pages 86 - 95
LEWIS, GENETIC ENGINEERING NEWS, vol. 12, no. 1, 1992
JAKOBOVITS ET AL., PNAS, vol. 90, 1993, pages 2551 - 255
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
GUATELLI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 1874 - 1878
"Short Protocols in Molecular Biology", 1992, GREEN PUBLISHING ASSOCIATES AND JOHN WILEY & SONS
See also references of EP 3615052A4
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
Download PDF: