Title:
USE OF HUMAN PLATELET-APOPTOTIC VESICLES
Document Type and Number:
WIPO Patent Application WO/2023/168921
Kind Code:
A1
Abstract:
Provided is the use of human platelet-apoptotic vesicles in the preparation of a formulation for promoting osteogenic differentiation of mesenchymal stem cells. Further provided is a bone defect repair formulation, comprising a PLGA scaffold material, wherein the human platelet-apoptotic vesicles are loaded on the surface of the PLGA scaffold material.
Inventors:
ZHOU YONGSHENG (CN)
ZHANG XIAO (CN)
JIANG YUHE (CN)
SHAO YUZI (CN)
YANG KUNKUN (CN)
ZHANG XIAO (CN)
JIANG YUHE (CN)
SHAO YUZI (CN)
YANG KUNKUN (CN)
Application Number:
PCT/CN2022/117997
Publication Date:
September 14, 2023
Filing Date:
September 09, 2022
Export Citation:
Assignee:
PEKING UNIV SCHOOL AND HOSPITAL OF STOMATOLOGY (CN)
International Classes:
A61K35/19; A61L27/18; A61L27/34; A61P19/08; C12N5/078
Foreign References:
| CN113943705A | 2022-01-18 | |||
| CN113559124A | 2021-10-29 | |||
| US20190290696A1 | 2019-09-26 | |||
| CN114306384A | 2022-04-12 |
Other References:
LI WENYUE, LIU YUNSONG, ZHANG PING, TANG YIMAN, ZHOU MIAO, JIANG WEIRAN, ZHANG XIAO, WU GANG, ZHOU YONGSHENG: "Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 6, 14 February 2018 (2018-02-14), US , pages 5240 - 5254, XP093090069, ISSN: 1944-8244, DOI: 10.1021/acsami.7b17620
ZHONGSHENG LIU, YANG JIANHONG: "Regulatory effect of uncarboxylated osteocalcin on osteogenic and adipogenic differentiation of mouse bone marrow mesenchymal stem cells under high-glucose conditions", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH JUNE, vol. 24, no. 13, 4 February 2020 (2020-02-04), pages 2039 - 2046, XP093090076, ISSN: 2095-4344, DOI: 10.3969/j.issn.2095-4344.2032
SEGHATCHIAN JERARD, KRAILADSIRI PRANEE: "What's happening? Platelet storage lesion and apoptosis: are they related?", TRANSFUSION AND APHERESIS SCIENCE, vol. 24, no. 1, 1 February 2001 (2001-02-01), pages 103 - 105, XP093090072
TORREGGIANI, E. ET AL.: "Exosomes: novel effectors of human platelet lysate activity", EUROPEAN CELLS AND MATERIALS, vol. 28, 31 December 2014 (2014-12-31), pages 137 - 151, XP002766230, DOI: 10.22203/eCM.v028a11
ZHONGSHENG LIU, YANG JIANHONG: "Regulatory effect of uncarboxylated osteocalcin on osteogenic and adipogenic differentiation of mouse bone marrow mesenchymal stem cells under high-glucose conditions", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH JUNE, vol. 24, no. 13, 4 February 2020 (2020-02-04), pages 2039 - 2046, XP093090076, ISSN: 2095-4344, DOI: 10.3969/j.issn.2095-4344.2032
SEGHATCHIAN JERARD, KRAILADSIRI PRANEE: "What's happening? Platelet storage lesion and apoptosis: are they related?", TRANSFUSION AND APHERESIS SCIENCE, vol. 24, no. 1, 1 February 2001 (2001-02-01), pages 103 - 105, XP093090072
TORREGGIANI, E. ET AL.: "Exosomes: novel effectors of human platelet lysate activity", EUROPEAN CELLS AND MATERIALS, vol. 28, 31 December 2014 (2014-12-31), pages 137 - 151, XP002766230, DOI: 10.22203/eCM.v028a11
Attorney, Agent or Firm:
BEIJING WANHUIDA LAW FIRM (CN)
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