Title:
USE OF HYALURONIC ACID OR SALT THEREOF AND/OR TREHALOSE IN STABILIZING ERGOTHIONEINE, AND ERGOTHIONEINE COMPOSITION CONTAINING HYALURONIC ACID OR SALT THEREOF AND/OR TREHALOSE
Document Type and Number:
WIPO Patent Application WO/2022/100567
Kind Code:
A1
Abstract:
The present application provides a use of a hyaluronic acid or a salt thereof and/or trehalose in stabilizing ergothioneine, an additive for stabilizing ergothioneine, the additive containing the hyaluronic acid or the salt thereof and/or trehalose, and a composition, the composition containing ergothioneine, the hyaluronic acid or the salt thereof, and trehalose. Compared with other auxiliary materials, the hyaluronic acid or the salt thereof and trehalose provided by the present invention can obviously mitigate the damage of a high temperature to ergothioneine, thereby increasing the yield of an ergothioneine powder product. The composition obtained by the present invention has good antioxidant and anti-apoptotic effects. Moreover, the inhibitory and scavenging effects of a composition obtained by compounding the hyaluronic acid or the salt thereof and trehalose to be used as an auxiliary material on intracellular reactive oxygen species are obviously better than those of a composition obtained by using a single hyaluronic acid or a salt thereof or trehalose as an auxiliary material.
Inventors:
WEI YUJIE (CN)
LU ZHEN (CN)
CHEN QINGPING (CN)
LI JIE (CN)
SUN YUANJUN (CN)
XIE WENJUAN (CN)
DU RANRAN (CN)
GUO WENYI (CN)
GUO XUEPING (CN)
LU ZHEN (CN)
CHEN QINGPING (CN)
LI JIE (CN)
SUN YUANJUN (CN)
XIE WENJUAN (CN)
DU RANRAN (CN)
GUO WENYI (CN)
GUO XUEPING (CN)
Application Number:
PCT/CN2021/129504
Publication Date:
May 19, 2022
Filing Date:
November 09, 2021
Export Citation:
Assignee:
BLOOMAGE BIOTECHNOLOGY CORP LTD (CN)
SHANDONG BLOOMAGE HYINC BIOPHARM CORPORATION LTD (CN)
SHANDONG BLOOMAGE HYINC BIOPHARM CORPORATION LTD (CN)
International Classes:
A61K31/4172; A61K47/26; A61K47/36; A61P17/16; A61P39/06
Foreign References:
| CN112353800A | 2021-02-12 | |||
| CN110327242A | 2019-10-15 | |||
| CN107114355A | 2017-09-01 | |||
| CN109938332A | 2019-06-28 | |||
| CN110522671A | 2019-12-03 |
Other References:
See also references of EP 4245304A4
Attorney, Agent or Firm:
BEIJING TANGSONG IP FIRM (CN)
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