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Title:
USE OF HYDROGEN PEROXIDE IN PREPARATION OF DRUGS FOR ERADICATION OF HELICOBACTER PYLORI INFECTION AND PREPARED DRUGS
Document Type and Number:
WIPO Patent Application WO/2020/082840
Kind Code:
A1
Abstract:
Disclosed are the use of hydrogen peroxide in preparation of drugs for eradication of Helicobacter pylori infection and the prepared drugs. The appropriate concentration of hydrogen peroxide quickly decomposes in the stomach and releases a large amount of oxygen, which significantly increases the oxygen concentration in the stomach, and enables effective eradication of Helicobacter pylori infection. The experiments show that the appropriate concentration of hydrogen peroxide has better killing effects on both Helicobacter pylori international standard strain and Helicobacter pylori wild type strain. The Helicobacter pylori infection model in mice shows no recurrence after treatment with hydrogen peroxide.

Inventors:
CAO YONGXIAO (CN)
DI JIA (CN)
CAO LEI (CN)
LIU JING (CN)
MI YANNI (CN)
YAO TONG (CN)
XIAO XUE (CN)
HUANG TINGTING (CN)
Application Number:
PCT/CN2019/098129
Publication Date:
April 30, 2020
Filing Date:
July 29, 2019
Export Citation:
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Assignee:
UNIV XI AN JIAOTONG (CN)
International Classes:
A61K33/40; A61P1/04; A61P31/04; A61P35/00
Foreign References:
CN109223825A2019-01-18
CN107519201A2017-12-29
Other References:
任滨成等 (REN, BINCHENG ET AL.): "双氧水治疗消化性溃疡21例 (Non-official translation: Treatment of 21 Cases of Peptic Ulcer with Hydrogen Peroxide)", 实用内科杂志 (CHINESE JOURNAL OF PRACTICAL INTERNAL MEDICINE), vol. 9, no. 7, 31 December 1989 (1989-12-31), DOI: 20191016142851X
刘玉珠等 (LIU, YUZHU ET AL.): "立体化治疗消化性溃疡173例临床分析 (The Effect of Three-dimensional Operation for 173 Patients with Peptic Ucer)", 中国医学创新 (MEDICAL INNOVATION OF CHINA), vol. 6, no. 35, 31 December 2009 (2009-12-31), DOI: 20191016143002A
Attorney, Agent or Firm:
XI'AN TONG DA PATENT AGENCY CO., LTD. (CN)
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