Title:
USE OF HYDROXYETHYL STARCH TO PREVENT POST SURGICAL ADHESION AND AS AN INTRACAVITY CARRIER DEVICE
Document Type and Number:
WIPO Patent Application WO1996040168
Kind Code:
A3
Abstract:
Hydroxyethyl starch (HES) and use thereof in methods are provided for reducing or preventing of adhesion formation between tissue surfaces, e.g., organ surfaces, in body cavities following surgical procedures and for drug delivery. HES may be used as an absorbable mechanical barrier alone or in combination with one or more anti-adhesion formation compounds for application to injured areas of tissues, e.g., organs, situated in body cavities such as the peritoneal, pelvic, pleural cavity, central nervous system and interligamentous space. HES may also be used as an intracavity carrier device for delivery of pharmaceutically active agents.
Inventors:
DIZEREGA GERE STODDER
Application Number:
PCT/US1996/008098
Publication Date:
January 23, 1997
Filing Date:
May 31, 1996
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
International Classes:
A61F2/82; A61K31/445; A61K31/495; A61K31/57; A61K31/715; A61K31/718; A61K45/00; A61K45/06; A61K47/36; A61P1/00; A61P41/00; A61P43/00; C08B11/08; (IPC1-7): A61K31/715
Foreign References:
| EP0602585A2 | 1994-06-22 | |||
| EP0234897A2 | 1987-09-02 |
Other References:
DATABASE WPI Week 9403, Derwent World Patents Index; AN 94-022820, XP002018924
R.G. STRAUSS ET AL.: "Effects of hydroxyethyl starch on fibrinogen, fibrin clot formation, and fibrinolysis.", TRANSFUSION, vol. 25, no. 3, 1985, pages 230-230 - 234, XP000609632
M.E. CARR JR.: "Effect of hydroxyethyl starch on the structure of thrombin- and reptilase-induced fibrin gels.", J. LAB. CLIN. MED., vol. 108, no. 6, 1986, pages 556 - 561, XP000609619
R.G. STRAUSS ET AL.: "Effects of hydroxyethyl starch on fibrinogen, fibrin clot formation, and fibrinolysis.", TRANSFUSION, vol. 25, no. 3, 1985, pages 230-230 - 234, XP000609632
M.E. CARR JR.: "Effect of hydroxyethyl starch on the structure of thrombin- and reptilase-induced fibrin gels.", J. LAB. CLIN. MED., vol. 108, no. 6, 1986, pages 556 - 561, XP000609619
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