Title:
USE OF AN INHIBITOR OF CATHEPSIN-S OR -B TO TREAT OR PREVENT CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Document Type and Number:
WIPO Patent Application WO2004089395
Kind Code:
A3
Abstract:
This invention is directed to the use of an inhibitor of cathepsin-S or -B, or composition thereof, to treat or prevent chronic obstruction pulmonary disease, or physiological condition associated therewith. Such a therapy would occur using at least one of such inhibitors alone or in combination with the other, or further in combination with an anti-inflammatory agent.
Inventors:
ZHENG TAO (US)
ELIAS JACK (US)
UNDERWOOD STEPHEN (US)
ELIAS JACK (US)
UNDERWOOD STEPHEN (US)
Application Number:
PCT/US2004/009959
Publication Date:
February 17, 2005
Filing Date:
April 01, 2004
Export Citation:
Assignee:
AVENTIS PHARMA INC (US)
UNIV YALE (US)
ZHENG TAO (US)
ELIAS JACK (US)
UNDERWOOD STEPHEN (US)
UNIV YALE (US)
ZHENG TAO (US)
ELIAS JACK (US)
UNDERWOOD STEPHEN (US)
International Classes:
A61K31/00; A61K38/00; (IPC1-7): A61K38/48
Domestic Patent References:
| WO2001019808A1 | 2001-03-22 | |||
| WO2000049007A1 | 2000-08-24 |
Other References:
BARNES P J: "Chronic obstructive pulmonary disease: new opportunities for drug development", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 19, no. 10, October 1998 (1998-10-01), pages 415 - 423, XP004156947, ISSN: 0165-6147
TAO ZHENG, ZHOU ZHU ET AL.: "Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema", JOURNAL OF CLINICAL INVESTIGATION, vol. 106, no. 9, 2000, pages 1081 - 1093, XP002307067
TAO ZHENG, ZHOU ZHU ET AL.: "Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema", JOURNAL OF CLINICAL INVESTIGATION, vol. 106, no. 9, 2000, pages 1081 - 1093, XP002307067
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