Title:
USE OF INTERLEUKIN-11 AS THERAPEUTIC AGENT FOR HEART DISEASE
Document Type and Number:
WIPO Patent Application WO/2008/050789
Kind Code:
A1
Abstract:
The object is to demonstrate the myocardial protection effect of interleukin-11 in vivo and provide a prophylactic or therapeutic agent for a heart disease or the like comprising interleukin-11 as an active ingredient. Interleukin-11 has a myocardial protection effect, and therefore can prevent the progress of a myocardial injury and also prevent the occurrence or progress of heart failure.
More Like This:
| WO/1995/000543 | ANTI-INFLAMMATORY PEPTIDES |
| WO/2002/097110 | TUMOR ENDOTHELIAL MARKER 7$g(a) MOLECULES AND USES THEREOF |
| JPS58225008 | PREPARATION OF PROLONGED ACTION COMPOUNDED SUBSTANCE |
Inventors:
AZUMA JUNICHI (JP)
FUJIO YASUSHI (JP)
KIMURA RYUSUKE (JP)
MAEDA MAKIKO (JP)
ARITA ATSUSHI (JP)
OBANA SATONORI (JP)
ITO TAKASHI (JP)
FUKUDA TSUYOSHI (JP)
FUJIO YASUSHI (JP)
KIMURA RYUSUKE (JP)
MAEDA MAKIKO (JP)
ARITA ATSUSHI (JP)
OBANA SATONORI (JP)
ITO TAKASHI (JP)
FUKUDA TSUYOSHI (JP)
Application Number:
PCT/JP2007/070699
Publication Date:
May 02, 2008
Filing Date:
October 24, 2007
Export Citation:
Assignee:
NEW IND RES ORGANIZATION (JP)
UNIV OSAKA (JP)
AZUMA JUNICHI (JP)
FUJIO YASUSHI (JP)
KIMURA RYUSUKE (JP)
MAEDA MAKIKO (JP)
ARITA ATSUSHI (JP)
OBANA SATONORI (JP)
ITO TAKASHI (JP)
FUKUDA TSUYOSHI (JP)
UNIV OSAKA (JP)
AZUMA JUNICHI (JP)
FUJIO YASUSHI (JP)
KIMURA RYUSUKE (JP)
MAEDA MAKIKO (JP)
ARITA ATSUSHI (JP)
OBANA SATONORI (JP)
ITO TAKASHI (JP)
FUKUDA TSUYOSHI (JP)
International Classes:
A61K38/00; A61P9/00; A61P9/04; A61P9/10; A61P39/06
Foreign References:
| JPH11508556A | 1999-07-27 | |||
| JPH11508556A | 1999-07-27 |
Other References:
KUENZLER K.A. ET AL.: "IL-11 pretreatment reduces cell death after intestinal ischemia-reperfusion", JOURNAL OF SURGICAL RESEARCH, vol. 108, no. 2, 2002, pages 268 - 272, XP003022372
ANCEY C. ET AL.: "Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture", CYTOKINE, vol. 18, no. 4, 2002, pages 199 - 205, XP003022373
CIRCULATION, vol. 108, 2003, pages 748 - 753
J BIOL CHEM., vol. 271, 1996, pages 9535 - 45
STEM CELLS, vol. 17, 1999, pages 127 - 37
ANNU REV IMMUNOL., vol. 15, 1997, pages 797 - 819
ANN.N.Y.ACAD.SCI, vol. 856, 1998, pages 12 - 21
J.IMMUNOL., vol. 157, 1997, pages 3627 - 3634
BLOOD, vol. 87, 1996, pages 3615 - 3624
GAN TO KAGAKU RYOHO, vol. 32, 2005, pages 489 - 96
GAN TO KAGAKU RYOHO, vol. 32, 2005, pages 479 - 87
KUNISADA ET AL., CIRCULATION, vol. 94, 1996, pages 2626 - 2632
WOLLERT ET AL., J BIOL CHEM., vol. 271, 1996, pages 9535 - 45
NAKAOKA ET AL., CIRC. RES., vol. 93, 2003, pages 221 - 229
ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FUJIO ET AL., CIRCULATION, vol. 101, 2000, pages 660 - 667
OSHIMA ET AL., CARDIOVASC. RES., vol. 65, 2005, pages 428 - 435
FUJIO ET AL., J. CLIN. INVEST., vol. 99, 1997, pages 2898 - 2905
ANCEY C. ET AL.: "Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture", CYTOKINE, vol. 18, no. 4, 2002, pages 199 - 205, XP003022373
CIRCULATION, vol. 108, 2003, pages 748 - 753
J BIOL CHEM., vol. 271, 1996, pages 9535 - 45
STEM CELLS, vol. 17, 1999, pages 127 - 37
ANNU REV IMMUNOL., vol. 15, 1997, pages 797 - 819
ANN.N.Y.ACAD.SCI, vol. 856, 1998, pages 12 - 21
J.IMMUNOL., vol. 157, 1997, pages 3627 - 3634
BLOOD, vol. 87, 1996, pages 3615 - 3624
GAN TO KAGAKU RYOHO, vol. 32, 2005, pages 489 - 96
GAN TO KAGAKU RYOHO, vol. 32, 2005, pages 479 - 87
KUNISADA ET AL., CIRCULATION, vol. 94, 1996, pages 2626 - 2632
WOLLERT ET AL., J BIOL CHEM., vol. 271, 1996, pages 9535 - 45
NAKAOKA ET AL., CIRC. RES., vol. 93, 2003, pages 221 - 229
ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FUJIO ET AL., CIRCULATION, vol. 101, 2000, pages 660 - 667
OSHIMA ET AL., CARDIOVASC. RES., vol. 65, 2005, pages 428 - 435
FUJIO ET AL., J. CLIN. INVEST., vol. 99, 1997, pages 2898 - 2905
Attorney, Agent or Firm:
SAEGUSA, Eiji et al. (1-7-1 Doshomachi, Chuo-k, Osaka-shi Osaka 45, JP)
Download PDF: