Title:
USE OF INTESTINAL MICROORGANISM AS MARKER OF BRONCHOPULMONARY DYSPLASIA IN PREMATURE INFANT
Document Type and Number:
WIPO Patent Application WO/2022/160358
Kind Code:
A1
Abstract:
The use of an intestinal microorganism as a marker of bronchopulmonary dysplasia in a premature infant. The intestinal microorganism is one or more of Klebsiella, Prevotella and Streptococcus. An isolated intestinal flora nucleic acid sample is sequenced to obtain a sequencing result; the relative abundance of the intestinal microorganism in the intestinal flora is detected according to the sequencing result, so as to obtain a relative abundance value; and the obtained relative abundance value of the intestinal microorganism is compared with a set value. The obtained result can be used as intermediate information to assist in the diagnosis of bronchopulmonary dysplasia in the premature infant. The 16SrDNA gene in a stool sample of the premature infant is sequenced by means of a high-throughput sequencing technique, and the relationship between the intestinal flora and the occurrence of BPD in the premature infant is discussed for the first time, thereby providing a reliable basis for the prevention and treatment of BPD.
Inventors:
ZHU XUEPING (CN)
ZHU XIAOLI (CN)
FAN JIAYING (CN)
LI JINGLAN (CN)
WU ZHIXIN (CN)
WANG HUAWEI (CN)
CHEN XIAOQIAN (CN)
YU YUN (CN)
ZHU XIAOLI (CN)
FAN JIAYING (CN)
LI JINGLAN (CN)
WU ZHIXIN (CN)
WANG HUAWEI (CN)
CHEN XIAOQIAN (CN)
YU YUN (CN)
Application Number:
PCT/CN2021/074737
Publication Date:
August 04, 2022
Filing Date:
February 01, 2021
Export Citation:
Assignee:
CHILDREN’S HOSPITAL OF SOOCHOW UNIV (CN)
International Classes:
C12Q1/689; C12Q1/06; C12Q1/10; C12Q1/14; C12R1/22; C12R1/46
Domestic Patent References:
| WO2018223146A1 | 2018-12-06 |
Foreign References:
| CN109715059A | 2019-05-03 | |||
| CN105543385A | 2016-05-04 | |||
| CN107034279A | 2017-08-11 | |||
| CN112831579A | 2021-05-25 |
Other References:
RYAN FEARGAL J., DREW DAMIAN, DOUGLAS CHLOE, LEONG LEX E. X., MOLDOVAN MAX, LYNN MIRIAM, FINK NAOMI, SRIBNAIA ANASTASIA, PENTTILA : "Changes in the Composition of the Gut Microbiota and the Blood Transcriptome in Preterm Infants at Less than 29 Weeks Gestation Diagnosed with Bronchopulmonary Dysplasia", MSYSTEMS, HIGHWIRE PRESS (FREE ACCESS), vol. 4, no. 5, 1 September 2019 (2019-09-01), pages 1 - 17, XP055954767, ISSN: 2379-5077, DOI: 10.1128/mSystems.00484-19
LIN PING; DING BINGYU; FENG CHUNYAN; YIN SHUWEI; ZHANG TING; QI XIN; LV HUIYING; GUO XIAOKUI; DONG KE; ZHU YONGZHANG; LI QINGTIAN: "Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder", JOURNAL OF AFFECTIVE DISORDERS., ELSEVIER BIOCHEMICAL PRESS, AMSTERDAM., NL, vol. 207, 1 October 2016 (2016-10-01), NL , pages 300 - 304, XP029804160, ISSN: 0165-0327, DOI: 10.1016/j.jad.2016.09.051
TIRONE CHIARA, PEZZA LUCILLA, PALADINI ANGELA, TANA MILENA, AURILIA CLAUDIA, LIO ALESSANDRA, D'IPPOLITO SILVIA, TERSIGNI CHIARA, P: "Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 10, 1 December 2019 (2019-12-01), Lausanne, CH , pages 2910 - 11, XP055954769, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02910
ALTHOUSE MELISSA H., KRITHIKA LINGAPPAN; WEIWU JIANG; CHRISTOPHER STEWART; BHAGAVATULA MOORTHY: "Role of Gut Microbiota in Neonatal Lung Injury: Implications for Bronchopulmonary Dysplasia | Pediatrics | American Academy of Pediatrics", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, US, vol. 144, 1 August 2019 (2019-08-01) - 6 November 2018 (2018-11-06), US , pages 1 - 3, XP055954772, ISSN: 0031-4005, DOI: 10.1542/peds.144.2MA7.682
ALTHOUSE MELISSA H., AMY HAIR; MIRIAM BALDERAS; ALAMELU VENKATACHALAM; STEVEN FORD; KRITHIKA LINGAPPAN; RUTH ANN LUNA: "Preterm Infants with Bronchopulmonary Dysplasia Develop a Less Diverse Intestinal Microbiome", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, US, vol. 144, no. 2_MeetingAbstract, 1 August 2019 (2019-08-01) - 6 November 2018 (2018-11-06), US , pages 676 - 676, XP055954794, ISSN: 0031-4005, DOI: 10.1542/peds.144.2MA7.676
CHEN SHAN-MING, LIN CHING-PIN, JAN MING-SHIOU: "Early Gut Microbiota Changes in Preterm Infants with Bronchopulmonary Dysplasia: A Pilot Case–Control Study", AMERICAN JOURNAL OF PERINATOLOGY, THIEME-STRATTON, NEW YORK, NY,, US, vol. 38, no. 11, 23 May 2020 (2020-05-23), US , pages 1142 - 1149, XP009538505, ISSN: 0735-1631, DOI: 10.1055/s-0040-1710554
PIERSIGILLI FIAMMETTA, VAN GRAMBEZEN BÉNÉDICTE, HOCQ CATHELINE, DANHAIVE OLIVIER: "Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle", NUTRIENTS, M D P I AG, CH, vol. 12, no. 2, 1 February 2020 (2020-02-01), CH , pages 469 - 23, XP055954811, ISSN: 2072-6643, DOI: 10.3390/nu12020469
LIN PING; DING BINGYU; FENG CHUNYAN; YIN SHUWEI; ZHANG TING; QI XIN; LV HUIYING; GUO XIAOKUI; DONG KE; ZHU YONGZHANG; LI QINGTIAN: "Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder", JOURNAL OF AFFECTIVE DISORDERS., ELSEVIER BIOCHEMICAL PRESS, AMSTERDAM., NL, vol. 207, 1 October 2016 (2016-10-01), NL , pages 300 - 304, XP029804160, ISSN: 0165-0327, DOI: 10.1016/j.jad.2016.09.051
TIRONE CHIARA, PEZZA LUCILLA, PALADINI ANGELA, TANA MILENA, AURILIA CLAUDIA, LIO ALESSANDRA, D'IPPOLITO SILVIA, TERSIGNI CHIARA, P: "Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 10, 1 December 2019 (2019-12-01), Lausanne, CH , pages 2910 - 11, XP055954769, ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02910
ALTHOUSE MELISSA H., KRITHIKA LINGAPPAN; WEIWU JIANG; CHRISTOPHER STEWART; BHAGAVATULA MOORTHY: "Role of Gut Microbiota in Neonatal Lung Injury: Implications for Bronchopulmonary Dysplasia | Pediatrics | American Academy of Pediatrics", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, US, vol. 144, 1 August 2019 (2019-08-01) - 6 November 2018 (2018-11-06), US , pages 1 - 3, XP055954772, ISSN: 0031-4005, DOI: 10.1542/peds.144.2MA7.682
ALTHOUSE MELISSA H., AMY HAIR; MIRIAM BALDERAS; ALAMELU VENKATACHALAM; STEVEN FORD; KRITHIKA LINGAPPAN; RUTH ANN LUNA: "Preterm Infants with Bronchopulmonary Dysplasia Develop a Less Diverse Intestinal Microbiome", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, US, vol. 144, no. 2_MeetingAbstract, 1 August 2019 (2019-08-01) - 6 November 2018 (2018-11-06), US , pages 676 - 676, XP055954794, ISSN: 0031-4005, DOI: 10.1542/peds.144.2MA7.676
CHEN SHAN-MING, LIN CHING-PIN, JAN MING-SHIOU: "Early Gut Microbiota Changes in Preterm Infants with Bronchopulmonary Dysplasia: A Pilot Case–Control Study", AMERICAN JOURNAL OF PERINATOLOGY, THIEME-STRATTON, NEW YORK, NY,, US, vol. 38, no. 11, 23 May 2020 (2020-05-23), US , pages 1142 - 1149, XP009538505, ISSN: 0735-1631, DOI: 10.1055/s-0040-1710554
PIERSIGILLI FIAMMETTA, VAN GRAMBEZEN BÉNÉDICTE, HOCQ CATHELINE, DANHAIVE OLIVIER: "Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle", NUTRIENTS, M D P I AG, CH, vol. 12, no. 2, 1 February 2020 (2020-02-01), CH , pages 469 - 23, XP055954811, ISSN: 2072-6643, DOI: 10.3390/nu12020469
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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