Title:
USE OF ISORHOIFOLIN AND DERIVATIVE THEREOF IN PROMOTING NERVE REPAIR
Document Type and Number:
WIPO Patent Application WO/2023/072069
Kind Code:
A1
Abstract:
Disclosed is the new use of Isorhoifolin and a derivative thereof. Isorhoifolin and the derivative thereof can be used for promoting the regeneration of damaged brain neurons and retinal nerves.
More Like This:
Inventors:
CHEN LINYI (CN)
CHEN YU-JEN (CN)
LIAO WEN-LING (CN)
WANG YI (CN)
LEE YU-TANG (CN)
LU TING-HSUAN (CN)
LI CHIA-WEI (CN)
CHEN FANG-YI (CN)
CHIAO CHUAN-CHIN (CN)
CHEN YU-JEN (CN)
LIAO WEN-LING (CN)
WANG YI (CN)
LEE YU-TANG (CN)
LU TING-HSUAN (CN)
LI CHIA-WEI (CN)
CHEN FANG-YI (CN)
CHIAO CHUAN-CHIN (CN)
Application Number:
PCT/CN2022/127372
Publication Date:
May 04, 2023
Filing Date:
October 25, 2022
Export Citation:
Assignee:
CHEN LINYI (CN)
CHEN YU JEN (CN)
CHEN YU JEN (CN)
International Classes:
C07H17/06; A61K31/35; A61P25/00
Foreign References:
| CN101045072A | 2007-10-03 |
Other References:
XU YAN, YE XIAOLEI, YAN WANG: "Hesperidin Alleviates Rotenone-induced Nerve Cell Damage", CHINESE JOURNAL OF CRITICAL CARE MEDICINE, vol. 12, no. 3, 30 June 2019 (2019-06-30), pages 182 - 186, XP009545238, ISSN: 1674-6880
XIAO BO; LI MENG;LI XIAO; WANG LIN-HONG: "Protective Effect of Hesperidin on Retinal Nerve Cells in Diabetic Rat", WORLD LATEST MEDICINE INFORMATION, vol. 19, no. 80, 31 December 2019 (2019-12-31), pages 26 - 27, XP009545237, ISSN: 1671-3141, DOI: 10.19613/j.cnki.1671-3141.2019.80.011
ZENG JIAJIA, HU WEILUN, LI HAO, LIU JIANGANG, ZHANG PENG, GU YANXIANG, YU YINGCHUN, WANG WENJUAN, WEI YUN: "Purification of linarin and hesperidin from Mentha haplocalyx by aqueous two‐phase flotation coupled with preparative HPLC and evaluation of the neuroprotective effect of linarin", JOURNAL OF SEPARATION SCIENCE, WILEY, DE, vol. 44, no. 12, 1 June 2021 (2021-06-01), DE , pages 2496 - 2503, XP093060942, ISSN: 1615-9306, DOI: 10.1002/jssc.202001243
YOKOYAMA, K. SHIMADA, Y. HORI, E. SEKIYA, N. GOTO, H. SAKAKIBARA, I. NISHIJO, H. TERASAWA, K.: "Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 6, 20 September 2004 (2004-09-20), AMSTERDAM, NL , pages 478 - 489, XP004957149, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2003.04.001
KUO PING-CHUNG, LIAO YU-REN, HUNG HSIN-YI, CHUANG CHIA-WEI, HWANG TSONG-LONG, HUANG SHIOW-CHYN, SHIAO YOUNG-JI, KUO DAIH-HUANG, WU: "Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis", MOLECULES, vol. 22, no. 6, 9 June 2017 (2017-06-09), pages 967, XP093060945, DOI: 10.3390/molecules22060967
XIAO BO; LI MENG;LI XIAO; WANG LIN-HONG: "Protective Effect of Hesperidin on Retinal Nerve Cells in Diabetic Rat", WORLD LATEST MEDICINE INFORMATION, vol. 19, no. 80, 31 December 2019 (2019-12-31), pages 26 - 27, XP009545237, ISSN: 1671-3141, DOI: 10.19613/j.cnki.1671-3141.2019.80.011
ZENG JIAJIA, HU WEILUN, LI HAO, LIU JIANGANG, ZHANG PENG, GU YANXIANG, YU YINGCHUN, WANG WENJUAN, WEI YUN: "Purification of linarin and hesperidin from Mentha haplocalyx by aqueous two‐phase flotation coupled with preparative HPLC and evaluation of the neuroprotective effect of linarin", JOURNAL OF SEPARATION SCIENCE, WILEY, DE, vol. 44, no. 12, 1 June 2021 (2021-06-01), DE , pages 2496 - 2503, XP093060942, ISSN: 1615-9306, DOI: 10.1002/jssc.202001243
YOKOYAMA, K. SHIMADA, Y. HORI, E. SEKIYA, N. GOTO, H. SAKAKIBARA, I. NISHIJO, H. TERASAWA, K.: "Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 6, 20 September 2004 (2004-09-20), AMSTERDAM, NL , pages 478 - 489, XP004957149, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2003.04.001
KUO PING-CHUNG, LIAO YU-REN, HUNG HSIN-YI, CHUANG CHIA-WEI, HWANG TSONG-LONG, HUANG SHIOW-CHYN, SHIAO YOUNG-JI, KUO DAIH-HUANG, WU: "Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis", MOLECULES, vol. 22, no. 6, 9 June 2017 (2017-06-09), pages 967, XP093060945, DOI: 10.3390/molecules22060967
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (GENERAL PARTNERSHIP) (CN)
Download PDF: