Title:
USE OF MICRORNA-7 IN PREPARATION OF DRUG FOR RESISTING GLIOSIS
Document Type and Number:
WIPO Patent Application WO/2016/206172
Kind Code:
A1
Abstract:
Provided is a use of MicroRNA-7 in preparation of drugs for suppressing gliosis of a nervous system. Overexpressing the MicroRNA-7 in a rat retina Muller cell line can reduce GMFB expression and inhibit generation of inflammatory factors. The MicroRNA-7 directly combines with a 3-UTR end of a GMFB mRNA to regulate expression of a GFAP protein.
Inventors:
XU GUOTONG (CN)
LU LIXIA (CN)
ZHANG JIEPING (CN)
TIAN HAIBIN (CN)
ZHANG JINGFA (CN)
WANG JUAN (CN)
LU LIXIA (CN)
ZHANG JIEPING (CN)
TIAN HAIBIN (CN)
ZHANG JINGFA (CN)
WANG JUAN (CN)
Application Number:
PCT/CN2015/085946
Publication Date:
December 29, 2016
Filing Date:
August 03, 2015
Export Citation:
Assignee:
UNIV TONGJI (CN)
International Classes:
A61K48/00; A61K31/7088; A61P25/00; A61P25/28
Domestic Patent References:
| WO2014071235A1 | 2014-05-08 | |||
| WO2014082644A1 | 2014-06-05 |
Foreign References:
| CN104940954A | 2015-09-30 | |||
| CN101054580A | 2007-10-17 | |||
| CN102573856A | 2012-07-11 | |||
| CN103620057A | 2014-03-05 |
Attorney, Agent or Firm:
SHANGHAI KESHENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
上海科盛知识产权代理有限公司 (CN)
上海科盛知识产权代理有限公司 (CN)
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