Title:
USE OF MICRORNA SIGNATURES FOR ASSESSING RISK LEVELS OF NEUROBLASTOMA PATIENTS
Document Type and Number:
WIPO Patent Application WO/2010/014975
Kind Code:
A3
Abstract:
Methods for assessing the risk level or survival/death probability of a neuroblastoma patient based on a number of microRNA signatures, optionally in combination with Dicer, Drosha, and age at diagnosis. Also disclosed herein is use of Dicer, Drosha, or both in suppressing neuroblastoma cell growth
Inventors:
YU ALICE L
LIN YOU-CHIN
LIN RUEY-JEN
LIN YOU-CHIN
LIN RUEY-JEN
Application Number:
PCT/US2009/052550
Publication Date:
May 06, 2010
Filing Date:
August 03, 2009
Export Citation:
Assignee:
ACADEMIA SINICA
YU ALICE L
LIN YOU-CHIN
LIN RUEY-JEN
YU ALICE L
LIN YOU-CHIN
LIN RUEY-JEN
International Classes:
C12Q1/68; A61P35/00; C12N15/10
Domestic Patent References:
| WO2008125883A1 | 2008-10-23 | |||
| WO2005118806A2 | 2005-12-15 |
Foreign References:
| US20060105360A1 | 2006-05-18 |
Other References:
YONGXIN CHEN ET AL.: "Differential Patterns of MicroRNA Expression in Neuroblastoma Are Correlated with Prognosis, Differentiation, and Apoptosis", CANCER RES., vol. 67, no. 3, 1 February 2007 (2007-02-01), pages 976 - 983
ELENA A AFANASYEVA ET AL.: "New miRNAs cloned from neuroblastoma", BNC GENOMICS, vol. 9, no. 52, 29 January 2008 (2008-01-29), pages 1 - 7
ELENA A AFANASYEVA ET AL.: "New miRNAs cloned from neuroblastoma", BNC GENOMICS, vol. 9, no. 52, 29 January 2008 (2008-01-29), pages 1 - 7
Attorney, Agent or Firm:
CHEN, Jenny et al. (10 Fawcett St.Cambridge, MA, US)
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